Disease Markers

Disease Markers / 2010 / Article
Special Issue

Combined Immunodeficiency Associated with DOCK8 Mutations and Related Immunodeficiencies

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Open Access

Volume 29 |Article ID 143612 | 10 pages | https://doi.org/10.3233/DMA-2010-0739

The Essential Role of DOCK8 in Humoral Immunity

Received14 Dec 2010
Accepted14 Dec 2010

Abstract

The processes that normally generate and maintain adaptive immunity and immunological memory are poorly understood, and yet of fundamental importance when infectious diseases place such a major economic and social burden on the world's health and agriculture systems. Defects in these mechanisms also underlie the many forms of human primary immunodeficiency. Identifying these mechanisms in a systematic way is therefore important if we are to develop better strategies for treating and preventing infection, inherited disease, transplant rejection and autoimmunity. In this review we describe a genome-wide screen in mice for the genes important for generating these adaptive responses, and describe two independent DOCK8 mutant mice strains identified by this screen. DOCK 8 was found to play an essential role in humoral immune responses and to be important in the proper formation of the B cell immunological synapse.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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