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Disease Markers
Volume 31, Issue 3, Pages 121-128

Classification of Cirrhosis: The Clinical Use of HVPG Measurements

Agustín Albilllos1 and Guadalupe Garcia-Tsao2

1Department of Gastoenterology and Hepatology, Hospital Ramón y Cajal, University of Alcalá, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Instituto de Salud Carlos III, Madrid, Spain
2Section of Digestives Diseases, Yale University School of Medicine, New Haven, CT, and VA-Connecticut Healthcare System, West Haven, CT, USA

Received 14 October 2011; Accepted 14 October 2011

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The modern paradigm considers cirrhosis as a dynamic and potentially reversible disease. It consists of two different entities, compensated and decompensated cirrhosis, each with a distinct prognosis and different predictors of survival. The development of portal hypertension is a hallmark in the history of cirrhosis, and its progression parallels that of the disease. In consequence, portal pressure measurement by means of HVPG allows stratifying cirrhosis in stages with defined outcomes, prognosis, and management strategies.