Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids

Demarco, Ana Lúcia G.; Rodrigues, Maria de Lourdes V.; Figueiredo, José Fernando C.; Deghaide, Neifi Hassam S.; de Menezes, Marcelo Bezerra; Demarco, Luís A.; Fernandes, Ana Paula M.; Donadi, Eduardo A.

doi:https://doi.org/10.3233/DMA-2012-00935

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Volume 33 | Article ID 612030 | https://doi.org/10.3233/DMA-2012-00935

Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids

Ana Lúcia G. Demarco,¹Maria de Lourdes V. Rodrigues,¹José Fernando C. Figueiredo,²Neifi Hassam S. Deghaide,²Marcelo Bezerra de Menezes,²Luís A. Demarco,¹Ana Paula M. Fernandes,³and Eduardo A. Donadi²

Received22 Oct 2012

Accepted22 Oct 2012

Abstract

Background/aims: The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC).Methods: 98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied.Results: The HLA-B35 was significantly increased in TRC group (p = 0.0038).Conclusion: The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.

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Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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