Background/aims: The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC).Methods: 98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied.Results: The HLA-B35 was significantly increased in TRC group (p = 0.0038).Conclusion: The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.