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Aurora a Overexpression and pVHL Reduced Expression Are Correlated with a Bad Kidney Cancer Prognosis
Imen Ferchichi
,1 Nadia Kourda,2 Samia Sassi,3 Khaled Ben Romdhane,3 Sarra Balatgi,2 Jean Yves Cremet,4 Claude Prigent,4 and Amel Benammar Elgaaied11Department of Biology, Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, Tunis, Tunisia
2Department of Histopathology, Charles Nicolle Hospital, Tunis, Tunisia
3Department of Histopathology, The Oncology Institute of Saleh Azaïez, Bab Saadoun, Tunis, Tunisia
4The Institute of Genetics and Development of Rennes, Rennes Cedex, France
Abstract
We investigate the expression and localization of the tumor suppressor protein pVHL as well as the oncoprotein Aurora A kinase in kidney cancer. Both Aurora A kinase and pVHL protein status were evaluated using immunohistochemistry. The Aurora A expression is correlated with the Fuhrman grade and the TNM stage, while the pVHL expression is correlated with the capsule rupture and the TNM stage. Aurora A kinase expression increases in malignant tissue comparing to the non-malignant one. And there is a decrease in pVHL expression from the adjacent healthy tissues to the tumor`s ones. The two kinds of opposite tumor profiles display significant distribution difference according to TNM stages. It could be proposed that the absence of Aurora A protein associated with a strong expression of pVHL in clear cells kidney carcinoma are of good prognosis for the disease.
Copyright
Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
