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Disease Markers
Volume 33, Issue 1, Pages 51-60

Cord Blood Levels of IL-6, IL-8 and IL-10 May Be Early Predictors of Bronchopulmonary Dysplasia in Preterm Newborns Small for Gestational Age

Gustavo Rocha,1 Elisa Proença,2 Ana Guedes,2 Carmen Carvalho,2 Augusta Areias,2 João Pedro Ramos,3 Teresa Rodrigues,4 and Hercília Guimarães1,5

1Division of Neonatology, Hospital de São João, Porto, Portugal
2Division of Neonatology, Centro Hospitalar do Porto, Porto, Portugal
3Division of Immunology, Hospital de São João, Porto, Portugal
4Department of Hygiene and Epidemiology, Faculty of Medicine of Porto University, Porto, Portugal
5Division of Neonatology, Hospital de São João, and Faculty of Medicine of Porto University, Porto, Portugal

Received 21 May 2012; Accepted 21 May 2012

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction: Various cytokines have been associated to the occurrence of bronchopulmonary dysplasia (BPD) in preterm neonates.

AIM: To establish an association between cord blood cytokines and BPD, so that they could be used, in clinical practice, as early markers of BPD.

Material and methods: Preterms less than 30 weeks gestational age, were analysed by ELISA microassay for venous cord blood IL-1β, IL-6, IL-8, TNF-α and IL-10, and compared between the BPD and non-BPD groups.

Results: One hundred and fifty neonates completed the study; 31 (21%) small for gestational age (SGA); 16 were deceased before 28 days of life; 36 developed mild BPD and 20 developed moderate/severe BPD. Elevated cord blood IL-8 was associated with death or moderate/severe BPD. SGA patients with moderate/severe BPD presented higher cord blood values of IL-8, lower IL-6 and IL-10 when compared with SGA without moderate/severe BPD; and higher IL-8 levels when compared with patients without moderate/severe BPD.

Conclusion: These results support an association between cord blood IL-8 and moderate/severe BPD, independently of the intra-uterine growth; and the association of cord blood IL-6 and IL-10 and moderate/severe BPD in SGA preterm newborns.