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Disease Markers
Volume 35, Issue 6, Pages 863–868
http://dx.doi.org/10.1155/2013/215407
Research Article

Positive Association between GCKR rs780093 Polymorphism and Coronary Heart Disease in the Aged Han Chinese

Jiangfang Lian,1 Jian Guo,1,2 Zhikui Chen,1 Qingjun Jiang,1 Huadan Ye,2 Xiaoyan Huang,2 Xi Yang,1 Yanna Ba,1,2 Jianqing Zhou,1 and Shiwei Duan2

1Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China
2Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University, Ningbo, Zhejiang 315211, China

Received 22 September 2013; Revised 31 October 2013; Accepted 31 October 2013

Academic Editor: Stamatios Theocharis

Copyright © 2013 Jiangfang Lian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “WHO publishes definitive atlas on global heart disease and stroke epidemic,” Indian Journal of Medical Sciences, vol. 58, pp. 405–406, 2004.
  2. V. L. Roger, A. S. Go, D. M. Lloyd-Jones et al., “Executive summary: heart disease and stroke statistics-2012 update: a report from the American heart association,” Circulation, vol. 125, no. 1, pp. 188–197, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Maouche and H. Schunkert, “Strategies beyond genome-wide association studies for atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 2, pp. 170–181, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. I. J. Kullo and K. Ding, “Mechanisms of disease: the genetic basis of coronary heart disease,” Nature Clinical Practice Cardiovascular Medicine, vol. 4, no. 10, pp. 558–569, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Mayer, J. Erdmann, and H. Schunkert, “Genetics and heritability of coronary artery disease and myocardial infarction,” Clinical Research in Cardiology, vol. 96, no. 1, pp. 1–7, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Pilia, W. Chen, A. Scuteri et al., “Heritability of cardiovascular and personality traits in 6,148 Sardinians,” PLoS Genetics, vol. 2, no. 8, article e132, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Zdravkovic, A. Wienke, N. L. Pedersen, M. E. Marenberg, A. I. Yashin, and U. de Faire, “Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins,” Journal of Internal Medicine, vol. 252, no. 3, pp. 247–254, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. Marenberg, N. Risch, L. F. Berkman, B. Floderus, and U. De Faire, “Genetic susceptibility to death from coronary heart disease in a study of twins,” The New England Journal of Medicine, vol. 330, no. 15, pp. 1041–1046, 1994. View at Publisher · View at Google Scholar · View at Scopus
  9. J. I. Cleeman, “Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III),” Journal of the American Medical Association, vol. 285, no. 19, pp. 2486–2497, 2001. View at Google Scholar · View at Scopus
  10. K. G. Alberti and P. Z. Zimmet, “Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation,” Diabetic Medicine, vol. 15, pp. 539–553, 1998. View at Google Scholar
  11. A. Patel, “Serum triglycerides as a risk factor for cardiovascular diseases in the Asia-Pacific region,” Circulation, vol. 110, no. 17, pp. 2678–2686, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Saxena, B. F. Voight, V. Lyssenko et al., “Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels,” Science, vol. 316, no. 5829, pp. 1331–1336, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. C. T. Johansen, S. Kathiresan, and R. A. Hegele, “Genetic determinants of plasma triglycerides,” Journal of Lipid Research, vol. 52, no. 2, pp. 189–206, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. E. van Schaftingen, “A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate,” European Journal of Biochemistry, vol. 179, no. 1, pp. 179–184, 1989. View at Google Scholar · View at Scopus
  15. A. T. Kraja, D. Vaidya, J. S. Pankow et al., “A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium,” Diabetes, vol. 60, no. 4, pp. 1329–1339, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Grimsby, J. W. Coffey, M. T. Dvorozniak et al., “Characterization of glucokinase regulatory protein-deficient mice,” The Journal of Biological Chemistry, vol. 275, no. 11, pp. 7826–7831, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Farrelly, K. S. Brown, A. Tieman et al., “Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 25, pp. 14511–14516, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Dupuis, C. Langenberg, I. Prokopenko et al., “New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk,” Nature Genetics, vol. 42, pp. 105–116, 2010. View at Google Scholar
  19. K. Shaye, T. Amir, S. Shlomo, and S. Yechezkel, “Fasting glucose levels within the high normal range predict cardiovascular outcome,” American Heart Journal, vol. 164, pp. 111–116, 2012. View at Google Scholar
  20. M. Li, B. McCulloch, and R. McDermott, “Metabolic syndrome and incident coronary heart disease in Australian indigenous populations,” Obesity, vol. 20, pp. 1308–1312, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. R. M. O'Doherty, D. L. Lehman, S. Télémaque-Potts, and C. B. Newgard, “Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia,” Diabetes, vol. 48, no. 10, pp. 2022–2027, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Ferre, E. Riu, F. Bosch, and A. Valera, “Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver,” The FASEB Journal, vol. 10, no. 10, pp. 1213–1218, 1996. View at Google Scholar · View at Scopus
  23. Z. C. J. Higgs, D. A. L. Macafee, B. D. Braithwaite, and C. A. Maxwell-Armstrong, “The Seldinger technique: 50 years on,” The Lancet, vol. 366, no. 9494, pp. 1407–1409, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Germer and R. Higuchi, “Single-tube genotyping without oligonucleotide probes,” Genome Research, vol. 9, no. 1, pp. 72–78, 1999. View at Google Scholar · View at Scopus
  25. L. Excoffier and H. E. L. Lischer, “Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows,” Molecular Ecology Resources, vol. 10, no. 3, pp. 564–567, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. P. C. Sham and D. Curtis, “Monte Carlo tests for associations between disease and alleles at highly polymorphic loci,” Annals of Human Genetics, vol. 59, no. 1, pp. 97–105, 1995. View at Google Scholar · View at Scopus
  27. W. D. Dupont and W. D. Plummer Jr., “Power and sample size calculations. A review and computer program,” Controlled Clinical Trials, vol. 11, no. 2, pp. 116–128, 1990. View at Publisher · View at Google Scholar · View at Scopus
  28. M. A. Williams, J. L. Fleg, P. A. Ades et al., “Secondary prevention of coronary heart disease in the elderly (with emphasis on patients ≥75 years of age): an american heart association scientific statement from the council on clinical cardiology subcommittee on exercise, cardiac rehabilitation, and prevention,” Circulation, vol. 105, no. 14, pp. 1735–1743, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Kathiresan, A. K. Manning, S. Demissie et al., “A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study,” BMC Medical Genetics, vol. 8, supplement 1, article S17, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. E. Warensjö, J. Sundström, B. Vessby, T. Cederholm, and U. Risérus, “Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study,” American Journal of Clinical Nutrition, vol. 88, no. 1, pp. 203–209, 2008. View at Google Scholar · View at Scopus
  31. J. A. Simon, M. L. Hodgkins, W. S. Browner, J. M. Neuhaus, J. T. Bernert Jr., and S. B. Hulley, “Serum fatty acids and the risk of coronary heart disease,” American Journal of Epidemiology, vol. 142, no. 5, pp. 469–476, 1995. View at Google Scholar · View at Scopus
  32. J. H. Wu, R. N. Lemaitre, A. Manichaikul et al., “Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium,” Circulation, vol. 6, pp. 171–183, 2013. View at Google Scholar
  33. S. Kathiresan, C. J. Willer, G. M. Peloso et al., “Common variants at 30 loci contribute to polygenic dyslipidemia,” Nature Genetics, vol. 41, no. 1, pp. 56–65, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. M. E. Keebler, R. C. Deo, A. Surti et al., “Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study,” Circulation, vol. 3, no. 4, pp. 358–364, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Orho-Melander, O. Melander, C. Guiducci et al., “Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations,” Diabetes, vol. 57, no. 11, pp. 3112–3121, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. N. L. Beer, N. D. Tribble, L. J. McCulloch et al., “The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver,” Human Molecular Genetics, vol. 18, no. 21, pp. 4081–4088, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. C. Ward-Caviness, C. Haynes, C. Blach, E. Dowdy, S. G. Gregory, S. H. Shah et al., “Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort,” Human Genetics, vol. 132, no. 12, pp. 1371–1382, 2013. View at Google Scholar