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Disease Markers
Volume 35, Issue 5, Pages 561–566
Review Article

Circulating microRNAs: A Potential Role in Diagnosis and Prognosis of Acute Myocardial Infarction

1Cardiology Department, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410078, China
2Cardiovascular Division, Department of Medicine, Center for Vascular Biology and Inflammation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02108, USA
3Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China

Received 14 August 2013; Accepted 30 September 2013

Academic Editor: Marco Peluso

Copyright © 2013 Ali Sheikh Md Sayed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Rapid and correct diagnosis of acute myocardial infarction (AMI) plays a crucial role in saving patients' life. Although some biomarkers (such as cardiac troponin and creatine kinase) are available for AMI diagnosis so far, there is still a clinical need for novel biomarkers, which can reliably rule in or rule out AMI immediately on admission. Circulating microRNAs (miRNAs) are a potential choice for novel biomarkers in AMI diagnosis and prognosis with high sensitivity and specificity. Circulating microRNAs are endogenous miRNAs that are detectable in whole blood, serum, or plasma in a highly stable form. Until now, around 20 circulating miRNAs were reported to be closely associated with AMI. In this minireview, we summarized recent available data on the correlation between circulating miRNAs and AMI. Some miRNAs, such as miR-208, miR-499, miR-133, and miR-1, were given special attention, since they may have a potential prospect in diagnosis and prognosis of AMI.