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Disease Markers
Volume 35, Issue 5, Pages 363–367
http://dx.doi.org/10.1155/2013/274515
Clinical Study

Diagnostic Significance of Serum Eotaxin-1 Level in Gastric Cancer Patients

1Department of Gastroenterologic Surgery, Turkiye Yuksek Ihtisas Education and Research Hospital, 06100 Ankara, Turkey
2Department of General Surgery, Ankara Numune Education and Research Hospital, 5.cadde 10/3 Bahçelievler, 06100 Ankara, Turkey
3Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, 34098 Istanbul, Turkey

Received 7 June 2013; Revised 5 August 2013; Accepted 23 August 2013

Academic Editor: Stamatios Theocharis

Copyright © 2013 Ümit Koç et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Gastric cancer is the second cause of cancer-related deaths worldwide. Delayed diagnosis leads to high mortality rates. Eotaxin-1 was originally discovered as an eosinophil-selective chemoattractant and may play a role in a number of chronic inflammatory diseases, cancer, and other gastrointestinal disorders. The aim of this study was to analyse diagnostic and prognostic significance of serum eotaxin-1 (s-eotaxin-1) levels in gastric cancer. Methods. Sixty gastric cancer patients and 69 healthy subjects were included into the study. S-eotaxin-1 levels were compared with clinicopathological features and outcomes in gastric cancer. Results. Serum levels of eotaxin-1 in gastric cancer patients were significantly higher than controls (  pg/mL versus  pg/mL, respectively ( )). The s-eotaxin-1 levels did not differ significantly with histopathological grade, tumor-node-metastasis (TNM) stage, tumor localization, lymph node metastases, positive lymph node ratio, size, perineural and perivascular invasion. So there is no relationship found between s-eotaxin-1 level and prognosis. Conclusion. S-eotaxin-1 levels may be used as an easily available biomarker for gastric cancer risk and may alert physicians for early diagnosis. Due to the limited number of patients included in this study, larger cohort studies are warranted to validate the diagnostic value of s-eotaxin-1 level in gastric cancer.