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Disease Markers
Volume 35, Issue 5, Pages 311–316
Research Article

Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis

1Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Bajaj Nagar, Nagpur 440010, India
2Environmental Genomics Unit, National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India

Received 10 June 2013; Revised 28 August 2013; Accepted 29 August 2013

Academic Editor: Silvia Persichilli

Copyright © 2013 Ruchika K. Jain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study was designed to investigate Rv2623 antigen, a major dormancy regulon protein of Mycobacterium tuberculosis (MTB) in CSF of suspected latent and active tuberculous meningitis (TBM) patients. A total of 100 CSF samples from TBM ( ), suspected latent TBM ( ), and suitable noninfectious control subjects ( ) were collected and evaluated for Rv2623 antigen level using ELISA protocol. A significantly high ( ) mean absorbance was observed in samples of suspected latent TBM and active TBM patients as compared to non-TBM control patients. However, no significant difference in Rv2623 level was observed between suspected latent TBM and TBM patients. Our preliminary findings suggest that Rv2623 may be useful as a potential biomarker for the diagnosis of the latent as well as active TBM infection. Futher evaluation of this biomarker in large number of samples is therefore needed to confirm the result.