Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis

Table 3

Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for Rv2623 Ag ELISA assay in TBM and suspected LTBM cases.

Group	TBM (𝑛=31)	Control (𝑛=47)	Sensitivity; % (95% CI)	Specificity; % (95% CI)	PPV; % (95% CI)	NPV; % (95% CI)
Rv2623 positive	28	0	90.32; (74.22–97.85)	100; (92.38–100)	100; (87.54–100)	94; (83.43–98.68)
Rv2623 negative	3	47
	Suspected LTBM (𝑛=22)
Rv2623 positive	17	0	77.27; (54.62–92.09)	100; (92.38–100)	100; (80.33–100)	90; (78.96–96.77)
Rv2623 negative	5	47

Note: sensitivity, specificity, PPV, and NPV were calculated on the basis of cut-off value (≥0.54) obtained from ROC curve analysis.