Interleukin 18 as a Marker of Chronic Nephropathy in Children after Anticancer Treatment
(a) Receiver operating characteristic (ROC) curve of IL-18 for the detection of nephropathy. The best cut-off threshold of >28.8 pg/mL allowed for a sensitivity of 51% and specificity of 88%. Area under the curve equaled (0.65; 95% Confidence Interval 0.53–0.77). (b) ROC curves for tubulopathy (solid line) and glomerulopathy (dashed line). The optimal cut-off value for diagnosing tubulopathy using IL-18 equaled 37.1 pg/mL which showed sensitivity of 66% and specificity of 86%; AUC equaled 0.78 (95% CI 0.69–0.88).
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