CD14 Gene Variants and Their Importance for Childhood Croup, Atopy, and Asthma

Table 2

Distribution of CD14 polymorphism and haplotypes by asthma, atopy, and croup.

	Asthma (𝑛=533)		Atopy (𝑛=499)		Croup (𝑛=533)
	Yes; 𝑛 (%)	No; 𝑛 (%)	Yes; 𝑛 (%)	No; 𝑛 (%)	Yes; 𝑛 (%)	No; 𝑛 (%)
Genotypes
CD14 C-159T
C/C	30 (19.2)	126 (80.8)	31 (21.8)	111 (78.2)	4 (2.6)^1	152 (97.4)
C/T	53 (18.8)	229 (81.2)	55 (20.5)	213 (79.5)	23 (8.2)	259 (91.8)
T/T	16 (16.8)	79 (83.2)	26 (29.2)	63 (70.8)	8 (8.4)	87 (91.6)
CD14 G-1359T
G/G	47 (15.6)^2	254 (84.4)	68 (23.6)	220 (76.4)	22 (7.3)	279 (92.7)
G/T	41 (21.5)	150 (78.5)	33 (18.9)	142 (81.1)	11 (5.8)	180 (94.2)
T/T	11 (26.8)	30 (73.2)	11 (30.6)	25 (69.4)	2 (4.9)	39 (95.1)
Haplotypes
C|G	28 (16.9)^3	138 (83.1)	31 (19.9)	125 (80.1)	8 (4.8)	158 (95.2)
C|T	29 (22.0)	103 (78.0)	27 (22.7)	92 (77.3)	8 (6.1)	124 (93.9)
T|G	39 (17.0)	191 (83.0)	53 (24.2)	166 (75.8)	19 (8.3)	211 (91.7)
T|T	3 (60.0)	2 (40.0)	1 (20.0)	4 (80.0)	0 (0.0)	5 (100.0)

𝑛 number and the numbers in parenthesis are the percentages. For genotype and haplotype analysis, significance difference of yes/no groups was performed using Fisher’s exact test.
¹𝑃=0.05,   ²𝑃=0.10,  ³𝑃=0.06.