CD14 Gene Variants and Their Importance for Childhood Croup, Atopy, and Asthma

Table 3

Multivariate logistic regression adjusted odds ratios for respiratory conditions for selected CD14 polymorphisms and haplotypes.

Models	Asthma (𝑛=533)		Atopy (𝑛=499)		Croup (𝑛=533)
	OR (95% CI)^#		OR (95% CI)^#		OR (95% CI)^#
Genotypes model
CD14 C-159T
C/C	1.00		1.00		1.00
C/T	1.20 (0.68, 2.11)		0.97 (0.55, 1.72)		3.79 (1.13, 12.74)
T/T	1.37 (0.61, 3.06)		1.40 (0.67, 2.94)		3.77 (0.89, 16.03)
CD14 G-1359T
G/G	1.00		1.00		1.00
G/T	1.65 (0.97, 2.80)		0.86 (0.51, 1.45)		0.98 (0.43, 2.25)
T/T	2.55 (1.05, 6.19)		1.63 (0.67, 3.97)		1.71 (0.31, 9.52)
Haplotypes model
C|G	1.00		1.00		1.00
C|T	1.36 (0.88, 2.10)		1.16 (0.77, 1.75)		$
T|G	1.04 (0.69, 1.57)		1.21 (0.82, 1.79)		$
T|T	7.17 (1.49, 34.40)		0.73 (0.08, 6.39)		$

#Adjusted for age, sex, ETS, and farming exposure. OR: odds ratio; CI: confidence interval. $Not reported due to zero counts in the cell of T|T with croup (see Table 2). Significance results are bold.