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Disease Markers
Volume 35, Issue 5, Pages 439–446
http://dx.doi.org/10.1155/2013/524106
Research Article

The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population

1Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, P.O. Box 57543, Makkah 21955, Saudi Arabia
2Department of Molecular Genetics, Medical Genetics Center, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
3Department of Psychiatry, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
4Department of Psychology, Faculty of Arts and Humanities, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia
5Department of Clinical Pathology, Medical Research Center, Faculty of Medicine, Ain Shams University, P.O. Box 80200, Cairo 11566, Egypt
6Department of Anatomy, Faculty of Medicine, Umm Al-Qura University, P.O. Box 7607, Makkah 21955, Saudi Arabia

Received 15 July 2013; Revised 18 September 2013; Accepted 20 September 2013

Academic Editor: Fabrizia Bamonti

Copyright © 2013 Nasser Attia Elhawary et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Biscaro, O. Lindvall, G. Tesco, C. T. Ekdahl, and R. M. Nitsch, “Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer’s disease,” Neurodegenerative Diseases, vol. 9, pp. 187–198, 2012. View at Publisher · View at Google Scholar
  2. C. P. Ferri, M. Prince, C. Brayne et al., “Global prevalence of dementia: a Delphi consensus study,” The Lancet, vol. 366, no. 9503, pp. 2112–2117, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. J. J. L. Rodriguez, C. P. Ferri, D. Acosta et al., “Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey,” The Lancet, vol. 372, no. 9637, pp. 464–474, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. G. K. York III and D. A. Steinberg, “Neurology in ancient Egypt,” in Handbook of Clinical Neurology, vol. 95, chapter 3, pp. 29–36, Elsevier, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. E. H. Jiffri and N. A. Elhawary, “The impact of common tumor necrosis factor haplotypes on the development of asthma in children: an egyptian model,” Genetic Testing and Molecular Biomarkers, vol. 15, no. 5, pp. 293–299, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. H. N. El Tallawy, W. M. A. Farghly, G. A. Shehata et al., “Prevalence of dementia in Al Kharga District, New Valley Governorate, Egypt,” Neuroepidemiology, vol. 38, no. 3, pp. 130–137, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. M. S. Saarela, T. Lehtimäki, J. O. Rinne et al., “No association between the brain-derived neurotrophic factor 196G>A or 270C>T polymorphisms and Alzheimer's or Parkinson's disease,” Folia Neuropathologica, vol. 44, no. 1, pp. 12–16, 2006. View at Google Scholar · View at Scopus
  8. S. J. Duthie, L. J. Whalley, A. R. Collins, S. Leaper, K. Berger, and I. J. Deary, “Homocysteine, B vitamin status, and cognitive function in the elderly,” The American Journal of Clinical Nutrition, vol. 75, pp. 908–913, 2002. View at Google Scholar
  9. E. Moore, A. Mander, D. Ames, R. Carne, K. Sanders, and D. Watters, “Cognitive impairment and vitamin B12: a review,” International Psychogeriatrics, vol. 24, no. 4, pp. 541–556, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. E. A. Varga, A. C. Sturm, C. P. Misita, and S. Moll, “Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease,” Circulation, vol. 111, no. 19, pp. e289–e293, 2005. View at Google Scholar · View at Scopus
  11. I. M. van Beynum, M. den Heijer, H. J. Blom, and L. Kapusta, “The MTHFR 677C → T polymorphism and the risk of congenital heart defects: a literature review and meta-analysis,” QJM, vol. 100, no. 12, pp. 743–753, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Chen, M. D. Gammon, W. Chan et al., “One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer,” Cancer Research, vol. 65, no. 4, pp. 1606–1614, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Bjelland, G. S. Tell, S. E. Vollset, H. Refsum, and P. M. Ueland, “Folate, vitamin B12, homocysteine, and the MTHFR 677C→T polymorphism in anxiety and depression. The Hordaland Homocysteine Study,” Archives of General Psychiatry, vol. 60, no. 6, pp. 618–626, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Frosst, H. J. Blom, R. Milos et al., “A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase,” Nature Genetics, vol. 10, no. 1, pp. 111–113, 1995. View at Google Scholar · View at Scopus
  15. P. Ventura, R. Panini, C. Verlato, G. Scarpetta, and G. Salvioli, “Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects,” Metabolism, vol. 50, no. 12, pp. 1466–1471, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Seshadri, A. Beiser, J. Selhub et al., “Plasma homocysteine as a risk factor for dementia and Alzheimer's disease,” The New England Journal of Medicine, vol. 346, no. 7, pp. 476–483, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Flicker, R. N. Martins, J. Thomas et al., “B-vitamins reduce plasma levels of beta amyloid,” Neurobiology of Aging, vol. 29, no. 2, pp. 303–305, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. M. C. Morris, D. A. Evans, J. A. Schneider, C. C. Tangney, J. L. Bienias, and N. T. Aggarwal, “Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 9, no. 4, pp. 435–443, 2006. View at Google Scholar · View at Scopus
  19. A. R. Koudinov and N. V. Koudinova, “Cholesterol homeostasis failure as a unifying cause of synaptic degeneration,” Journal of the Neurological Sciences, vol. 229-230, pp. 233–240, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Religa, M. Styczynska, B. Peplonska et al., “Homocysteine, apolipoproteine E and methylenetetrahydrofolate reductase in Alzheimer's disease and mild cognitive impairment,” Dementia and Geriatric Cognitive Disorders, vol. 16, no. 2, pp. 64–70, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. M. R. Keikhaee, S. B. Hashemi, H. Najmabadi, and M. Noroozian, “C677T methylentetrahydrofulate reductase and angiotensin converting enzyme gene polymorphisms in patients with Alzheimer's disease in Iranian population,” Neurochemical Research, vol. 31, no. 8, pp. 1079–1083, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. S. P. McIlroy, K. B. Dynan, J. T. Lawson, C. C. Patterson, and A. P. Passmore, “Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland,” Stroke, vol. 33, no. 10, pp. 2351–2356, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Wang, F. Jin, R. Kan et al., “Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease,” Journal of Molecular Neuroscience, vol. 27, no. 1, pp. 23–28, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. L. L. Fernandez and R. M. Scheibe, “Is MTHFR polymorphism a risk factor for Alzheimer's disease like APOE?” Arquivos de Neuro-Psiquiatria, vol. 63, no. 1, pp. 1–6, 2005. View at Google Scholar · View at Scopus
  25. Y. D. Zhang, X. Y. Ke, W. Shen, and Y. Liu, “Relationship of homocysteine and gene polymorphisms of its related metabolic enzymes with Alzheimer’s disease,” Chinese Medical Sciences Journal, vol. 20, no. 4, pp. 247–251, 2005. View at Google Scholar
  26. D. Seripa, G. Dal Forno, M. G. Matera et al., “Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients,” Neurobiology of Aging, vol. 24, no. 7, pp. 933–939, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Kida, K. Kamino, M. Yamamoto et al., “C677T polymorphism of methylenetetrahydrofolate reductase gene affects plasma homocysteine level and is a genetic factor of late-onset Alzheimer’s disease,” Psychogeriatrics, vol. 4, no. 1, pp. 4–10, 2004. View at Publisher · View at Google Scholar
  28. J. Chapman, N. Wang, T. A. Treves, A. D. Korczyn, and N. M. Bornstein, “ACE, MTHFR, factor V Leiden, and APOE polymorphisms in patients with vascular and Alzheimer's dementia,” Stroke, vol. 29, no. 7, pp. 1401–1404, 1998. View at Google Scholar · View at Scopus
  29. T. Brunelli, S. Bagnoli, B. Giusti et al., “The C677T methylenetetrahydrofolate reductase mutation is not associated with Alzheimer's disease,” Neuroscience Letters, vol. 315, no. 1-2, pp. 103–105, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. X.-H. Bi, H.-L. Zhao, Z.-X. Zhang, and J.-W. Zhang, “Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease,” Neurobiology of Aging, vol. 30, no. 10, pp. 1601–1607, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. J. A. Prince, L. Feuk, S. L. Sawyer et al., “Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease,” European Journal of Human Genetics, vol. 9, no. 6, pp. 437–444, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. J.-M. Kim, R. Stewart, S.-W. Kim et al., “Methylenetetrahydrofolate reductase gene and risk of Alzheimer's disease in Koreans,” International Journal of Geriatric Psychiatry, vol. 23, no. 5, pp. 454–459, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. R. M. Shawky, N. S. Sayed, and N. A. Elhawary, “Mutations in transglutaminase 1 gene in autosomal recessive congenital ichthyosis in Egyptian families,” Disease Markers, vol. 20, no. 6, pp. 325–332, 2004. View at Google Scholar · View at Scopus
  34. M.-Y. Zhang, L. Miao, Y.-S. Li, and G.-Y. Hu, “Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to Alzheimer's disease,” Neuroscience Research, vol. 68, no. 2, pp. 142–150, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Rocchi, S. Pellegrini, G. Siciliano, and L. Murri, “Causative and susceptibility genes for Alzheimer's disease: a review,” Brain Research Bulletin, vol. 61, no. 1, pp. 1–24, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. R. J. Guerreiro, E. Lohmann, E. Kinsella et al., “Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease,” Neurobiology of Aging, vol. 33, no. 5, pp. e17–e23, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. F. Coppedè, P. Tannorella, I. Pezzini et al., “Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls,” Antioxidants & Redox Signaling, vol. 17, no. 2, pp. 195–204, 2012. View at Publisher · View at Google Scholar
  38. J. Sundelöf, J. Sundström, O. Hansson et al., “Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls,” Journal of Alzheimer's Disease, vol. 22, no. 4, pp. 1223–1230, 2010. View at Google Scholar
  39. M. S. Kindy, J. Yu, H. Zhu, S. S. El-Amouri, V. Hook, and G. R. Hook, “Deletion of the cathepsin B gene improves memory deficits in a transgenic alzheimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence,” Journal of Alzheimer's Disease, vol. 29, no. 4, pp. 827–840, 2012. View at Publisher · View at Google Scholar · View at Scopus