The MTHFR 677T Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer’s Disease in an Egyptian Population

Table 2

Genotype distribution of the rs1801133 single nucleotide polymorphism and severity of Alzheimer’s disease.

Severity of Alzheimer’s disease^a	Patients; 𝑛 (%)	Genotype; 𝑛 (%)
		C/C	C/T	T/T
Mild	26 (60.5)	3 (7.0)	14 (32.6)	9 (20.9)
Moderate	6 (14.0)	1 (2.3)	1 (2.3)	4 (9.3)
Severe	11 (25.6)	4 (9.4)	2 (4.7)	5 (11.6)

aThe severity of Alzheimer’s disease was evaluated using stages of the clinical dementia rating (CDR). In this rating, a null value is used for no dementia; 0.5 for questionable dementia; and 1, 2, and 3 for mild, moderate, and severe dementia, respectively.