Disease Markers / 2013 / Article / Fig 3

Research Article

Novel Evolutionary Models and Periodic Charts in p- and q-Individual Chromosomes of Auxiliary Lymph Node and Buccal Cells

Figure 3

Protein expressions of Ki67, cyclin D1, and Cyclin E in auxiliary lymph node cells. (a1) ALN cells with dapi filter (blue), as counter stain; (a2) ALN cells conjugated with FITC (green), representative of Ki67 characterized with a minor cells with high expression by IF; (a3) same ALN cells as conjugated with Pe-Cy5 (red), representative of cyclin D1with low expression; (a4) same cells were conjugated with R-Pe (orange), representative of Cyclin E reflecting high expression in certain cell population, and harmonic expression mode in similar bunch of cells as observed in expression of Ki67; (b1) merged image of Ki67 and cyclin D1; (b2) merged image of Ki67 and cyclin E; (b3) merged image shows coexpression of Ki67, cyclin D1, and cyclin E; (c) reflects merge of dapi, Ki67, cyclin D1, and cyclin E. The merged images clarify the diverse and heterogenic expression of two key cell cycle targets; that is, cyclin D1 and cyclin E enable initiating proliferative manner; this is accompanied by the active role of Ki67 as a growth and proliferative index in the present benign neoplastic tissue, that is, ALN.

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