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Disease Markers
Volume 35, Issue 6, Pages 607–613
Research Article

Is Human Papillomavirus Associated with Prostate Cancer Survival?

1Oncology Institute of Southern Switzerland (IOSI), Ospedale San Giovanni, 6500 Bellinzona, Switzerland
2Department of Medical Sciences, University of Trieste, Cattinara Hospital, I-34149 Trieste, Italy

Received 24 June 2013; Revised 10 September 2013; Accepted 7 October 2013

Academic Editor: Ahmed O. Kaseb

Copyright © 2013 Mariarosa Pascale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The role of human papillomavirus (HPV) in prostate carcinogenesis is highly controversial: some studies suggest a positive association between HPV infection and an increased risk of prostate cancer (PCa), whereas others do not reveal any correlation. In this study, we investigated the prognostic impact of HPV infection on survival in 150 primary PCa patients. One hundred twelve (74.67%) patients had positive expression of HPV E7 protein, which was evaluated in tumour tissue by immunohistochemistry. DNA analysis on a subset of cases confirmed HPV infection and revealed the presence of genotype 16. In Kaplan-Meier analysis, HPV-positive cancer patients showed worse overall survival (OS) (median 4.59 years) compared to HPV-negative (median 8.24 years, ). In multivariate analysis age ( ), Gleason score ( ), nuclear grading ( ), and HPV status ( ) were independent prognostic factors for OS. In our cohort, we observed high prevalence of HPV nuclear E7 oncoprotein and an association between HPV infection and PCa survival. In the debate about the oncogenic activity of HPV in PCa, our results further confirm the need for additional studies to clarify the possible role of HPV in prostate carcinogenesis.