Is Human Papillomavirus Associated with Prostate Cancer Survival?

Table 1

Univariate and multivariate analyses of prognostic factors in 150 patients with primary prostate cancer. Univariate analysis was performed by using the Kaplan-Meier method. Multivariate analysis was done by the Cox proportional hazards model.

Variable	Patients; 𝑛 = 150 (%)	Deaths; 𝑛 = 132 (%)	Univariate			Multivariate
			Median survival time (years)	95% CI	𝑃 value	Hazard ratio	Standard error	95% CI	𝑃 value
Age (years)
≤72	85 (56.67)	69 (52.27)	6.87	5.15–9.29	<0.001*	2.15	0.39	1.51–3.06	<0.001*
>72	65 (43.33)	63 (47.73)	3.14	1.82–3.63
Nuclear grade
1	23 (15.33)	18 (13.64)	13.60	6.21–15.13	<0.001*
2	99 (66.00)	86 (65.15)	5.14	4.12–6.73		1.53	0.42	0.91–2.62	0.105
3	28 (18.67)	28 (21.21)	2.56	1.34–3.63		2.76	0.92	1.43–5.31	0.002*
Capsule infiltration
Negative	84 (56.37)	71 (54.20)	6.21	4.72–8.79
Positive	65 (43.63)	60 (45.80)	3.30	1.89–4.95	0.0159*
1 missing
Gleason score
<7	64 (42.67)	49 (37.12)	10.78	6.91–13.60	<0.001*	2.53	0.51	1.70–3.75	<0.001*
≥7	86 (57.33)	83 (62.88)	3.28	1.85–4.59
Nuclear
E7 expression
Negative	38 (25.33)	30 (22.73)	8.24	3.63–11.81	0.0381*	1.57	0.33	1.03–2.39	0.034*
Positive	112 (74.67)	102 (77.27)	4.59	3.45–5.35

CI: confidence interval; *significant value.