Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia

Table 4

The five most significantly overrepresented canonical pathways identified by Ingenuity Pathway Analysis based on a list of 200 genes with expression associated with treatment response × probeset or medication × treatment response × probeset.

Treatment response × probeset (𝑛=200 genes)	B-H P value
Axonal guidance signaling	0.04
Cholecystokinin/gastrin-mediated signaling	0.22
Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis	0.22
ERK/MAPK signaling	0.26
VEGF signaling	0.26
Medication × treatment response × probeset (𝑛=200 genes)	B-H P value
Α-adrenergic signaling	0.01
Reelin signaling in neurons	0.02
Insulin receptor signaling	0.03
Fcγ receptor-medicated phagocytosis in macrophages and monocytes	0.03
CREB signaling in neurons	0.03

B-H P value: Benjamini-Hochberg false discovery rate.