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Disease Markers
Volume 35 (2013), Issue 5, Pages 389–394
http://dx.doi.org/10.1155/2013/803240
Clinical Study

Crevicular Fluid and Serum Concentrations of Progranulin and High Sensitivity CRP in Chronic Periodontitis and Type 2 Diabetes

1Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka 560002, India
2Bangalore Medical College and Research Institute, Bangalore, Karnataka 560002, India
3Department of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bangalore, Karnataka 560002, India

Received 11 March 2013; Revised 13 June 2013; Accepted 4 August 2013

Academic Editor: Marco Peluso

Copyright © 2013 N. Priyanka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. This study was designed to correlate the serum and gingival crevicular fluid (GCF) levels of progranulin (PGRN) and high sensitivity C-reactive protein (hs CRP) in chronic periodontitis and type 2 diabetes mellitus (DM). Design. PGRN and hs CRP levels were estimated in 3 groups: healthy, chronic periodontitis, and type 2 DM with chronic periodontitis. Results. The mean PGRN and hs CRP concentrations in serum and GCF were the highest for group 3 followed by group 2 and the least in group 1. Conclusion. PGRN and hs CRP may be biomarkers of the inflammatory response in type 2 DM and chronic periodontitis.