Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress

Table 3

Results for BPD. Genotype distribution as numbers of individuals for each genotype. 𝑃 values are given in accordance with Hardy-Weinberg equilibrium (HWE) and for association with BPD by Armitage’s trend test.

Gene	Polymorphism	Genotypes; BPD	HWE; BPD	Genotypes; controls	HWE; controls	𝑃 values for association
MMP-1	rs1799750	16, 25, 14	0,590	34, 44, 39	0.009	0.532
	rs7125062	41, 15, 3	0,364	74, 43, 11	0.241	0.126
MMP-2	rs7201	21, 28, 9	1,000	43, 64, 21	0.860	0.747
	rs243865	35, 18, 6	0,170	80, 35, 12	0.013	0.675
	rs17301608	27, 25, 11	0,280	51, 63, 21	0.857	0.769
MMP-9	rs20544	17, 19, 17	0,053	27, 60, 37	0.856	0.508
	rs3918242	35, 12, 4	0,077	76, 36, 4	1.000	0.894
	rs17576	24, 18, 12	0,042	57, 46, 22	0.032	0.639
MMP-12	rs2276109	44, 13, 2	0,328	86, 38, 2	0.522	0.574
	rs652438	52, 8, 0	1,000	10, 19, 1	0.587	0.615
MMP-16	rs2664352	12, 31, 19	1,000	40, 57, 35	0.120	0.185
FGFR-2	rs2981579	21, 32, 10	0,799	51, 58, 25	0.281	0.858
	rs1219648	19, 33, 12	0,804	52, 61, 20	0.854	0.215
FGFR-4	rs376618	35, 23, 5	0,744	84, 40, 10	0.132	0.432
	rs1966265	47, 15, 1	0,473	79, 45, 9	1.000	0.023
FGF-2	rs11938826	48, 14, 1	1,000	96, 38, 1	0.305	0.557
FGF-3	rs11263591	25, 22, 15	0,037	45, 61, 29	0.382	0.710
	rs10796856	17, 26, 22	0,135	37, 59, 40	0.125	0.632
FGF-4	rs3740639	33, 23, 7	0,365	74, 46, 15	0.086	0.815
FGF-7	rs16962440	17, 35, 12	0,614	42, 70, 25	0.730	0.656
FGF-7, C15 or f33	rs4316697	28, 30, 4	0,377	65, 55, 15	0.550	0.868
FGF-7, C15 or f33	rs10519230	37, 23, 3	1,000	73, 50, 11	0.517	0.421
FGF-18	rs4559013	22, 23, 17	0,045	45, 62, 22	1.000	0.387
SIRPA	rs3828016	20, 31, 12	1,000	48, 59, 27	0.288	0.788
	rs4814734	16, 37, 10	0,206	46, 62, 25	0.598	0.553
TTF-1	rs11628131	20, 27, 16	0,311	54, 50, 29	0.012	0.287
	rs999460	34, 19, 11	0,019	60, 51, 24	0.040	0.414