Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress

Table 4

Results for RDS. Genotype distribution as numbers of individuals for each genotype. 𝑃 values are given for Hardy-Weinberg equilibrium (HWE) and for association with RDS.

Gene	Polymorphism	Genotypes RDS	HWE; RDS	Genotypes controls	HWE controls	𝑃 value for association
MMP-1	rs1799750	25, 44, 20	1,000	24, 29, 33	0.004	0.163
	rs7125062	51, 36, 10	0.003	66, 21, 9	0.330	0.076
MMP-2	rs7201	30, 49, 16	0.678	34, 43, 16	0.067	0.648
	rs243865	58, 26, 11	0.012	58, 27, 7	0.139	0.540
	rs17301608	42, 47, 18	0,422	37, 43, 14	0.827	0.838
MMP-9	rs20544	29, 34, 24	0,828	14, 44, 30	0.052	0.033
	rs3918242	55, 23, 6	0,178	57, 25, 2	1.000	0.421
	rs17576	38, 30, 21	0,005	45, 34, 13	0.153	0.164
MMP-12	rs2276109	67, 27, 2	1,000	64, 23, 1	1.000	0.595
	rs652438	89, 10, 0	1,000	73, 17, 1	1.000	0.047
MMP-16	rs2664352	26, 46, 27	0,546	26, 43, 27	0.312	0.998
FGFR-2	rs2981579	33, 40, 20	0,840	40, 52, 15	0.289	0.351
	rs1219648	42, 49, 16	0,837	30, 47, 16	0.833	0.347
FGFR-4	rs376618	71, 27, 9	0,018	51, 36, 6	1.000	0.286
	rs1966265	76, 28, 2	1,000	50, 35, 8	0.605	0.003
FGF-2	rs11938826	80, 26, 1	0,690	67, 26, 1	0.684	0.586
FGF-3	rs11263591	31, 48, 25	0,438	40, 37, 19	0.085	0.127
	rs10796856	33, 50, 26	0,442	21, 38, 36	0.092	0.036
FGF-4	rs3740639	57, 41, 7	1,000	50, 30, 16	0.009	0.209
FGF-7	rs16962440	30, 57, 21	0,566	30, 49, 17	0.836	0.588
FGF-7 C15 or f33	rs4316697	56, 43, 7	1,000	38, 44, 12	1.000	0.044
FGF-7, C15 or f33	rs10519230	61, 41, 5	0,790	51, 33, 9	0.301	0.418
FGF-18	rs4559013	32, 45, 26	0,236	35, 43, 13	1.000	0.079
SIRPA	rs3828016	34, 53, 21	1,000	37, 38, 19	0.134	0.487
	rs4814734	31, 58, 18	0,334	32, 43, 17	0.674	0.671
TTF-1	rs11628131	36, 47, 23	0,326	41, 30, 22	0.002	0.453
	rs999460	56, 37, 16	0,027	38, 36, 19	0.082	0.121