Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis

Table 2

GCF mediator levels at baseline, peak of induction (day 21), and at resolution (day 35) of experimental gingivitis.

	Baseline	Day 21	Day 35	𝐹 statistic	𝑃 value
IL-1𝛽 (pg/mL)	52.91 (9.13)	91.93 (33.15)	9.64 (6.01)	(1.09, 7.63) = 4.37	0.070*
IL-2 (pg/mL)	7.81 (1.39)	11.82 (3.98)	0.59 (0.39)	(1.16, 8.11) = 5.97	0.037*
IL-4 (pg/mL)	0.19 (0.07)	0.48 (0.22)	0 (0)	(1.16, 8.07) = 3.36	0.101*
IL-5 (pg/mL)	0.16 (0.16)	0.97 (0.59)	1.22 (0.51)	(2, 14) = 1.40	0.279
IL-6 (pg/mL)	14.96 (3.50)	26.84 (8.18)	1.68 (1.68)	(2, 14) = 6.16	0.012
IL-10 (pg/mL)	0 (0)	0.58 (0.58)	0 (0)	(2, 14) = 1	0.393
IL-12(p70) (pg/mL)	0.04 (0.04)	0.18 (0.14)	0 (0)	(1.12, 7.9) = 1.21	0.312*
IL-13 (pg/mL)	0 (0)	0.13 (0.13)	0 (0)	(2, 14) = 1	0.393
IFN-𝛾 (pg/mL)	0.96 (0.21)	2.2 (0.84)	0.09 (0.09)	(1.1, 7.7) = 4.60	0.063*
TNF-𝛼 (pg/mL)	0.98 (0.19)	1.75 (0.57)	0.11 (0.11)	(1.18, 8.29) = 6.47	0.03*
sICAM-1 (ng/mL)	0 (0)	4.64 (4.64)	16.58 (10.87)	(2, 14) = 2.10	0.160
CRP (ng/mL)	0 (0)	10.25 (10.25)	5.89 (5.89)	(2, 14) = 0.54	0.600

Mediator levels are expressed as mean (SE).
*Greenhouse-Geisser correction for nonsphericity.