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Disease Markers
Volume 2014, Article ID 161954, 5 pages
http://dx.doi.org/10.1155/2014/161954
Research Article

Preoperative Serum Levels of Mesothelin in Patients with Colon Cancer

1Şişli Hamidiye Etfal Training and Research Hospital General Surgery Clinic, Istanbul, Turkey
2Department of General Surgery, Yuzuncu Yil University Medical Faculty, Van, Turkey
3Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey
4Department of Biostatistics, Istanbul University Medical Faculty, Istanbul, Turkey
5Department of Radiology, Yuzuncu Yil University Medical Faculty, Van, Turkey

Received 9 August 2014; Revised 26 October 2014; Accepted 27 October 2014; Published 13 November 2014

Academic Editor: Marco E. M. Peluso

Copyright © 2014 Özgür Bostancı et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Screening for biochemical markers is important for diagnosing colon cancer. In this study, the reliability of serum mesothelin levels as a potential diagnostic and screening instrument was evaluated concerning colon cancer. Methods. Ninety-five patients who had undergone colonoscopic examination and who were diagnosed with colon cancer were included in the study. The serum mesothelin levels were measured with the ELISA kits and were evaluated in terms of significant difference when compared between colon cancer and control group. Results. Patients with colon cancer had significantly higher mesothelin serum levels than the control groups. We found significant associations between serum levels and tumor grade, perineural invasion, and vascular invasion (resp., ). Conclusion. Evaluating the serum levels of mesothelin has a potential to detect and screen the colon cancer in affected patients. Our data suggest that mesothelin exhibits effects towards colon cancer and serves as a biomarker for this deadly disease.