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Disease Markers
Volume 2014, Article ID 192836, 11 pages
Review Article

Renal Biopsy: Use of Biomarkers as a Tool for the Diagnosis of Focal Segmental Glomerulosclerosis

1Pathology Laboratory, Nephropathology Service, Federal University of Triângulo Mineiro, 38015-150 Uberaba, MG, Brazil
2Immunology Laboratory, Department of Biological Sciences, Federal University of Triângulo Mineiro, 58051-900 Uberaba, MG, Brazil
3Human Immunology Research and Education Group, Technical Health School of UFPB, Federal University of Paraíba, 38025-180 João Pessoa, PB, Brazil

Received 26 November 2013; Revised 15 January 2014; Accepted 15 January 2014; Published 25 February 2014

Academic Editor: Vincent Sapin

Copyright © 2014 Crislaine Aparecida da Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis.