Research Article
Immunohistochemical Correlation of Matrix Metalloproteinase-2 and Tissue Inhibitors of Metalloproteinase-2 in Tobacco Associated Epithelial Dysplasia
Table 2
Expression of MMP-2 and TIMP-2 in cells of basal and parabasal layers and fibroblasts in all the grades of dysplasia.
| Cells | Dysplasia | MMP-2 score | Total | Chi-square | value* | TIMP-2 score | Total | Chi-square | value* | ā | + | ++ | ā | + | ++ |
| Basal | Normal | 10 | 0 | 0 | 10 | 35.833 | <0.001 | 10 | 0 | 0 | 10 | 39.461 | <0.001 | Mild | 5 | 5 | 0 | 10 | 1 | 9 | 0 | 10 | Moderate | 0 | 7 | 3 | 10 | 0 | 8 | 2 | 10 | Severe | 0 | 4 | 6 | 10 | 0 | 7 | 3 | 10 | Total | 15 | 16 | 9 | 40 | 11 | 24 | 5 | 40 |
| Parabasal | Normal | 10 | 0 | 0 | 10 | 33.461 | <0.001 | 10 | 0 | 0 | 10 | 32.923 | <0.001 | Mild | 5 | 5 | 0 | 10 | 3 | 7 | 0 | 10 | Moderate | 1 | 9 | 0 | 10 | 0 | 10 | 0 | 10 | Count | 1 | 5 | 4 | 10 | 0 | 9 | 1 | 10 | Total | 17 | 19 | 4 | 40 | 13 | 26 | 1 | 40 |
| Fibroblast | Normal | 10 | 0 | 0 | 10 | 46.582 | <0.001 | 10 | 0 | 0 | 10 | 38.156 | <0.001 | Mild | 1 | 9 | 0 | 10 | 1 | 9 | 0 | 10 | Moderate | 0 | 9 | 1 | 10 | 0 | 10 | 0 | 10 | Severe | 0 | 5 | 5 | 10 | 0 | 9 | 1 | 10 | Total | 11 | 23 | 6 | 40 | 11 | 28 | 1 | 40 |
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MMP-2: matrix metalloproteinase-2; TIMP-2: tissue inhibitor of metalloproteinase-2.
*Kruskal-Wallis test.
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