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Disease Markers
Volume 2014, Article ID 231736, 8 pages
http://dx.doi.org/10.1155/2014/231736
Research Article

Prediabetes Is Associated with HNF-4α P2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis

1Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China
2Shenzhen Shekou People's Hospital, Shenzhen 518067, China
3The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, China
4School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Diabetes Center, Ningbo University, Ningbo 315211, China

Received 5 July 2014; Accepted 11 September 2014; Published 15 October 2014

Academic Editor: Stamatios Theocharis

Copyright © 2014 Changyi Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Controversy remains for the association between hepatocyte nuclear factor (HNF-4α) P2 promoter polymorphism rs1884613 and type 2 diabetes (T2D). There was no association test of this polymorphism with prediabetes and T2D in the Chinese population. Moreover, an updated meta-analysis in various ethnic groups is needed to establish the contribution of rs1884613 to T2D risk. Methods. Using the Sequenom MassARRAY platform approach, we genotyped rs1884613 of HNF-4α in the P2 promoter region among 490 T2D patients, 471 individuals with prediabetes, and 575 healthy controls. All the individuals were recruited from 16 community health service centers in Nanshan district in Shenzhen province. Using STATA 11.0 software, meta-analysis was performed to summarize the overall contribution of rs1884613 to T2D risk. Results. Polymorphism rs1884613 was associated with genetic susceptibility to prediabetes in the whole samples (OR = 1.40, 95% CI = 1.16–1.68, ) and the female subgrouped samples (OR = 1.48, 95% CI = 1.14–1.92, ) after adjusting for age and body mass index (BMI). In contrast, there was no association of rs1884613 with T2D in the whole samples and male in our case-control study and meta-analysis. Conclusions. Our results suggest that rs1884613 contributes to susceptibility to prediabetes, whereas this polymorphism may not play an important role in the development of T2D.