Prediabetes Is Associated with HNF-4α P2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis

Table 4

The characteristics of each study included in meta-analysis.

Study	Country/racial decent	Publication year	Source of controls	Minor allele		Major allele		Sample size		(HNF)- rs1884613
										Case			Control
				Case	Control	Case	Control	Case	Control	CC	CG	GG	CC	CG	GG
American Diabetes Association [12]	Finland; Scandinavia	2010	Family based and population based	0.21	0.16	0.79	0.84	787	410	498	254	35	291	105	14
Dupont and Plummer [13]	America Ashkenazi Jewish	1990	Family based	0.27	0.21	0.73	0.79	275	342	—	—	—	—	—	—
Silander et al. [15]	America Caucasian	2004	Hospital; based	0.171	0.172	0.829	0.828	300	310	—	—	—	—	—	—
Boj et al. [8]	Discordant sibs	2001	Population based	0.19	0.18	0.81	0.82	609	580	—	—	—	—	—	—
	Canada			0.12	0.17	0.88	0.83	471	471	—	—	—	—	—	—
	Scandinavia			0.20	0.19	0.80	0.81	127	127	—	—	—	—	—	—
	Sweden			0.19	0.15	0.81	0.85	514	514	—	—	—	—	—	—
	GCI USA			0.15	0.17	0.85	0.83	1226	1226	—	—	—	—	—	—
	GCI Poland			0.17	0.18	0.83	0.82	1009	1009	—	—	—	—	—	—
Winter [7]	Japan; Japanese	2003	Hospital; based	0.482	0.469	0.518	0.531	192	192	59	81	52	53	98	41
Love-Gregory et al. [16]	Japan; Japanese	2004	Hospital; based	0.477	0.474	0.523	0.526	925	893	—	—	—	—	—	—
Higgins and Thompson [14]	Norway; Scandinavia	2002	Population based	0.198	0.181	0.802	0.819	1644	1879	1048	507	67	1224	531	63
The present study	China; Chinese	2014	Population based	0.43	0.43	0.57	0.57	490	575	148	260	79	171	288	94

Genomics Collaborative, Inc. (GCI).