Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome

Table 2

Analysis of the expression of IL-6, TNF-𝛼, and CRP in the liver of perinatal autopsies.

Groups	𝑁 (%)	% IL-6	% CRP	% TNF-α
	48 (100)	Median (minimum–maximum)
(A) Cause of death
Perinatal anoxia	21 (43.75)	26.86 (2.41–88.18)^1,3	3.07 (0.03–58.06)^5	10.46 (0.01–54.89)^10,11
Ascending infection	15 (31.25)	29.51 (1.26–78.75)^2,3	5.22 (0.00–62.69)^4,5	4.75 (0.02–57.44)^9,11
Congenital malformation	12 (25.00)	32.91 (2.00–79.64)^1,2	2.61 (0.02–46.83)^4	9.30 (0.05–82.39)^9,10
		𝐻=42.911;𝑃≤0.001	𝐻=28.920;𝑃≤0.001	𝐻=101.374;𝑃≤0.001
(B) Type of stress
Chronic	36 (75.00)	27.85 (1.26–70.38)	3.63 (0.00–62.69)	8.35 (0.01–57.44)
Acute	12 (25.00)	32.91 (2.00–79.64)	2.61 (0.02–46.83)	9.30 (0.05–82.39)
		𝑈=1341457.000;𝑃≤0.001	𝑈=1212794.000;𝑃≤0.001	𝑈=1437612.000;𝑃=0.003
(C) Gestational age (GA)
Term birth	11 (22.92)	25.97 (1.26–71.32)	8.45 (0.04–62.69)	7.39 (0.01–50.27)
Premature	37 (77.08)	29.82 (2.00–70.38)	2.85 (0.00–58.06)	9.22 (0.05–63.36)
		𝑈=1052865.000;𝑃≤0.001	𝑈=1449215.000;𝑃≤0.001	𝑈=1159934.500;𝑃=0.249
(D) Weight for GA
SGA	6 (12.50)	27.42 (1.97–76.64)	4.79 (0.01–46.12)^7,8	16.05 (0.02–82.39)^12,13
LGA	12 (25.00)	29.76 (2.45–88.18)	5.89 (0.08–58.06)^6	8.20 (0.04–55.02)^12
AGA	30 (62.50)	29.40 (1.26–70.38)	2.67 (0.00–62.69)^6,7,8	8.43 (0.01–57.44)^13
		𝐻=0.0892;𝑃=0.956	𝐻=109.947;𝑃≤0.001	𝐻=30.065;𝑃≤0.001

 ^{1 to 13} Dunn, 𝑃: <0.05. SGA: small for gestational age, LGA: large for gestational age, AGA: appropriate for gestational age.