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Disease Markers
Volume 2014, Article ID 278715, 9 pages
Review Article

Chemokines as Potential Markers in Pediatric Renal Diseases

1Unidade de Nefrologia Pediátrica, Departamento de Pediatria, Universidade Federal de Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, Brazil
2Instituto Nacional de Ciência e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, UFMG, 30130-100 Belo Horizonte, MG, Brazil
3Laboratório Interdisciplinar de Investigação Médica Faculdade de Medicina, UFMG, Avenida Alfredo Balena 190, 2nd Floor, Room No.281, 30130-100 Belo Horizonte, MG, Brazil
4Departamento de Nefrologia, Santa Casa de Misericordia de Belo Horizonte, 30130-100 Belo Horizonte, MG, Brazil
5Laboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, UFMG, 31270-901 Belo Horizonte, MG, Brazil

Received 29 June 2013; Accepted 2 January 2014; Published 17 February 2014

Academic Editor: Francisco Blanco-Vaca

Copyright © 2014 Ana Cristina Simões e Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Glomerular diseases and obstructive uropathies are the two most frequent causes of chronic kidney disease (CKD) in children. Recently, biomarkers have become a focus of clinical research as potentially useful diagnostic tools in pediatric renal diseases. Among several putative biomarkers, chemokines emerge as promising molecules since they play relevant roles in the pathophysiology of pediatric renal diseases. The evaluation of these inflammatory mediators might help in the management of diverse renal diseases in children and the detection of patients at high risk to develop CKD. The aim of this paper is to revise general aspects of chemokines and the potential link between chemokines and the most common pediatric renal diseases by including experimental and clinical evidence.