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Disease Markers
Volume 2014 (2014), Article ID 291419, 10 pages
http://dx.doi.org/10.1155/2014/291419
Research Article

A New Susceptibility Locus for Myocardial Infarction, Hypertension, Type 2 Diabetes Mellitus, and Dyslipidemia on Chromosome 12q24

1Genetics Department, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
2King Faisal Heart Institute, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
3Cardiovascular and Pharmacogenomics Unit, MBC-03-05, Genetics Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia

Received 28 January 2014; Revised 15 May 2014; Accepted 28 May 2014; Published 26 June 2014

Academic Editor: Claudio Letizia

Copyright © 2014 Salma M. Wakil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We examined the role of hepatic nuclear factor-1 alpha (HNF1a) gene polymorphism on coronary artery disease (CAD) traits in 4631 Saudi angiographed individuals (2419 CAD versus 2212 controls) using TaqMan assay on ABI Prism 7900HT sequence detection system. Following adjustment for confounders, the rs2259820_CC (1.19 (1.01–1.42); ), rs2464196_TT (1.19 (1.00–1.40); ), and rs2259816_T (1.13 (1.01–1.26); ) were associated with MI. The rs2259820_T (1.14 (1.03–1.26); ) and rs2464196_C (1.12 (1.02–1.24); ) were associated with type 2 diabetes mellitus (T2DM), while the rs2393791_T (1.14 (1.01–1.28); ), rs7310409_G (1.16 (1.03–1.30); ), and rs2464196_AG+GG (1.25 (1.05–1.49); ) were implicated in hypertension. Hypertriglyceridemia was linked to the rs2393791_T (1.14 (1.02–1.27); ), rs7310409_G (1.12 (1.01–1.25); ), rs1169310_G (1.15 (1.04–1.28); ), and rs1169313_CT+TT (1.24 (1.06–1.45); ) and high low density lipoprotein-cholesterol levels were associated with rs2259820_T (1.23 (1.07–1.41); ), rs2464196_T (1.22 (1.06–1.39); ), and rs2259816_T (1.18 (1.02–1.36); ). A 7-mer haplotype CATATAC ( ; ), constructed from the studied SNPs, was associated with MI, and CATATA implicated in T2DM ( ; ). Hypertriglyceridemia was linked to TGCGGG ( ; ), and obesity to ACGGGT ( ; ). Our results suggest that the HNF1a is a common susceptibility gene for MI, T2DM, hypertension, and dyslipidemia.