A New Susceptibility Locus for Myocardial Infarction, Hypertension, Type 2 Diabetes Mellitus, and Dyslipidemia on Chromosome 12q24

Figure 1

Schematic diagram representation of some of the pathways regulated by HNF1a. AES: androgen receptor nuclear signaling, Wnt signalling pathway. CREBBP: Notch signaling pathways, signaling by Notch1. CTNNB1: androgen receptor nuclear signaling, Wnt signalling pathway. DYRK1B: glucose/energy metabolism. HDAC1: Notch signaling pathways, signaling by Notch1. HNF1a: maturity onset diabetes of the young (MODY), type II diabetes mellitus, presenilin action in Notch and Wnt signaling, and metabolism. PCBD1: metabolism. PCBD2: metabolism. PDX1: maturity onset diabetes of the young, type II diabetes mellitus. SLC2A2: maturity onset diabetes of the young, type II diabetes mellitus. TLE1: Wnt signaling pathway, signaling by Notch1, and presenilin action in Notch and Wnt signaling.