A New Susceptibility Locus for Myocardial Infarction, Hypertension, Type 2 Diabetes Mellitus, and Dyslipidemia on Chromosome 12q24
Table 1
Demographics and important clinical data of the studied myocardial infarction disease group and controls.
(a) Demographics of the coronary artery disease set.
Controls
Cases
All
Male
Female
All
Male
Female
CAD
2212
1183 (53.5)
1029 (46.5)
2419
1852 (76.6)
567 (23.4)
Age
47.1 ± 0.4
47.2 ± 0.6
47.1 ± 0.4
59.7 ± 0.2
59.3 ± 0.2
60.8 ± 0.4
BMI
28.9 ± 0.2
29.9 ± 0.2
30.0 ± 0.3
29.2 ± 0.1
28.3 ± 0.1
31.6 ± 0.2
FH
536
293 (54.7)
243 (45.3)
381
307 (80.6)
74 (19.4)
T2DM
893
479 (53.6)
414 (46.4)
1657
1227 (74.0)
430 (26.0)
HTN
1490
774 (51.9)
716 (45.1)
2038
1532 (75.2)
506 (24.8)
OBS
854
363 (42.5)
491 (57.5)
905
601 (66.4)
304 (33.6)
hChol
566
289 (51.1)
277 (48.9)
1113
823 (73.9)
290 (26.1)
hLDLC
272
144 (52.9)
128 (47.1)
359
262 (73.0)
225 (27.0)
lHDLC
695
458 (65.9)
237 (34.1)
1230
1019 (82.8)
448 (17.2)
hTG
402
248 (61.7)
154 (38.3)
758
577 (76.1)
181 (23.9)
Smokers
653
607 (93.0)
46 (7.0)
1108
1079 (97.4)
29 (2.6)
VD
One
0
0
0
918
667 (72.7)
251 (27.3)
Two
0
0
0
483
378 (78.3)
105 (21.7)
Multiple
0
0
0
1018
807 (79.3)
211 (20.7)
The numbers in brackets give the percentages of the total (all) values of the group. BMI: body mass index; FH: family history of CAD; hLDLC: high low-density lipoprotein-cholesterol level; lHDLC: low high-density lipoprotein-cholesterol level; hTG: hypertriglyceridemia; hChol: hypercholesterolemia; HTN: hypertension; OBS: obesity; T2DM: type 2 diabetes mellitus; VD: number of diseased vessels.
(b) Demographics for the studied coronary artery disease traits.
Controls
Cases
All
Male
Female
All
Male
Female
MI
1587
786 (49.5)
801 (50.5)
3044
2249 (97.9)
795 (26.1)
T2DM
2081
1329 (63.9)
752 (36.1)
2550
1706 (66.9)
844 (33.1)
HTN
1103
729 (66.1)
374 (33.9)
3528
2306 (65.4)
1222 (34.6)
OBS
2573
1876 (72.9)
697 (27.1)
1759
964 (54.8)
795 (45.2)
hChol
2733
1793 (65.6)
940 (34.4)
1679
1112 (66.2)
567 (33.8)
hLDLC
3681
2438 (66.2)
1243 (33.8)
631
406 (64.3)
225 (35.7)
lHDLC
2393
1369 (57.2)
1024 (42.8)
1925
1477 (76.7)
448 (23.3)
hTG
3156
2019 (64.0)
1137 (36.0)
1160
825 (71.1)
335 (28.9)
The numbers in brackets give the percentages of the total (all) values of the group. hChol: hypercholesterolemia; hLDLC: high low-density lipoprotein-cholesterol level; hTG: hypertriglyceridemia; HTN: hypertension; lHDLC: low high-density lipoprotein-cholesterol level; OBS: obesity; MI: myocardial infarction; T2DM: type 2 diabetes mellitus.
