A New Susceptibility Locus for Myocardial Infarction, Hypertension, Type 2 Diabetes Mellitus, and Dyslipidemia on Chromosome 12q24
Table 3
Association of selected HNF1a haplotypes with disease.
Block
Haplotype
Pooled
Cases
Control
value
Myocardial infarction
1–7
CATATAC
0.505
0.516
0.486
7.50
0.0062*
TGCGGGT
0.356
0.346
0.375
7.42
0.0064*
CATAGAC
0.011
0.009
0.014
6.06
0.014
1–6
CATATA
0.504
0.514
0.484
7.48
0.0062*
TGCGGG
0.357
0.349
0.484
5.81
0.0159
CATAGA
0.011
0.009
0.015
7.66
0.0056*
ATATAC
0.505
0.515
0.486
6.90
0.0086*
GCGGGT
0.357
0.347
0.374
6.47
0.011*
1–5
CATAT
0.503
0.513
0.483
7.68
0.0056*
TGCGG
0.361
0.353
0.377
5.22
0.022
CATAG
0.012
0.009
0.016
7.28
0.007*
3–7
TATAC
0.514
0.525
0.494
7.97
0.0048
CGGGT
0.396
0.387
0.412
5.33
0.021
2–6
ATATA
0.504
0.514
0.485
7.02
0.0081*
GCGGG
0.359
0.351
0.374
4.94
0.026
2–5
ATAT
0.503
0.513
0.484
6.70
0.0096*
3–6
TATA
0.514
0.525
0.493
8.36
0.0038**
4–7
ATAC
0.515
0.525
0.496
7.26
0.0071*
1–4
CATA
0.513
0.521
0.498
4.36
0.037
Hypertriglyceridemia
1–6
TGCGGG
0.357
0.376
0.352
4.26
0.039
1–5
TGCGG
0.361
0.380
0.355
4.61
0.032
3–7
CGGGT
0.396
0.415
0.390
4.23
0.039
2–6
GCGGG
0.359
0.377
0.353
3.90
0.048
4–7
GGGT
0.395
0.414
0.390
4.27
0.039
Obesity
2–7
ACGGGT
0.04
0.046
0.036
5.04
0.025
2–6
ACGGG
0.04
0.047
0.036
5.84
0.016
Type 2 diabetes mellitus
1–7
CATATAC
0.505
0.515
0.494
3.94
0.047
1–4
CATA
0.513
0.523
0.502
3.96
0.047
The table shows selected haplotypes associated with disease. The most frequent 7-mer haplotype CATATAC (0.505) was employed as the baseline to determine the relative effects of the other haplotypes. The studied SNPs are (1) rs2393791, (2) rs7310409, (3) rs2259820, (4) rs2464196, (5) rs2259816, (6) rs1169310, and (7) rs1169313 arranged sequentially by their chromosomal positions, and blocks represent the range of variants constituting the respective haplotypes. ; by test.
