Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development

Table 1

Summary of the role of ANXA2 acting as a marker in tumors.

Cancer	Expression	Method	Clinical relevance	Reference
ALL	Up	WB, qRT-PCR	Resistant to prednisolone	[57]
APL	Up	IFA	Hemorrhagic complications	[58]
B-cell lymphoma	Up	WB	None	[91]
ccRCC	Up	IHC	Metastasis	[92]
Breast	Up	Northern blot, WB	Migration and invasion; Herceptin-resistance	[59, 74]
Breast	Up	IHC	Metastasis; Neoangiogenesis	[59, 72]
Cervical	Up	IHC	Poor survival rate; Poor differentiation; Chemoresistance	[107]
CRC	Up	IHC	Poor survival rate; Recurrence; Poor differentiation	[75]
ESCC	Down	IHC, qRT-PCR, WB	Poor differentiation; Lymph node metastasis	[94]
Gastric cancer	Up	IHC	Depth of invasion; Lymph node metastasis and distant metastasis; TNM stage	[61, 78]
Glioma	Up	WB	Invasion and angiogenesis	[69]
HCC	Up	ELISA	Diagnostic marker in early stage	[82]
HCC	Up	IHC, WB	Poor differentiation; Diagnostic marker	[63]
Lung	Up	IHC, IFA	Tumor size and grade; Pleural invasion; Poor prognosis	[64, 86]
MM	Up	Flow cytometry	Poor prognosis; Poor survival	[87]
Osteosarcoma	Down	RT-PCR, WB, IFA	Poor differentiation; Metastasis	[96]
OSCC	Up	IHC, WB, qRT-PCR	Tumor size and frequent recurrence, well differentiation	[67]
Pancreatic	Up	ELISA	Good survival	[89]
Pancreatic	Up	Northern blot, WB	Proliferation	[69]
Prostate	Down	IHC, WB	Advanced clinical stage; More frequent recurrence; Regional lymph node and distant metastasis	[73, 100]

WB: western blot; qRT-PCR: quantitative reverse transcription polymerase chain reaction; IFA: immunofluorescence assay; IHC: immunohistochemistry; ELISA: enzyme-linked immunosorbent assay.