Research Article

Promoter Methylation of SFRP3 Is Frequent in Hepatocellular Carcinoma

Table 3

Frequency of SFRP3 promoter methylation in 30 control livers and 60 paired HCC and adjacent nontumor tissue samples.

DiagnosisNo. of cases with SFRP3 methylation value

Control livers* ( )0 (0%)<0.0001
Chronic hepatitis ( )6 (16.2%)
Cirrhosis ( )9 (39.1%)
HCC ( )36 (60%)

Thirty control tissues were from 30 hepatic hemangiomas. Statistical analysis was determined by chi-square test.