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Disease Markers
Volume 2014, Article ID 480201, 7 pages
Research Article

Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals

1Laboratory of Genetics and Molecular Hematology (LIM31), University of São Paulo School of Medicine, 05403-000 São Paulo, SP, Brazil
2Research Division, Pró-Sangue Hemocentro de São Paulo Foundation, 05403-000 São Paulo, SP, Brazil
3Department of Clinical Laboratory, Health Sciences Center, Federal University of Santa Catarina, 88040-900 Florianópolis, SC, Brazil
4Clinics of Parasitic and Infectious Diseases, Hospital and Clinics of the University of São Paulo School of Medicine, 05403-000 São Paulo, SP, Brazil
5Lipid Metabolism Laboratory, Heart Institute, University of São Paulo School of Medicine, 05403-000 São Paulo, SP, Brazil

Received 26 September 2013; Revised 30 December 2013; Accepted 14 January 2014; Published 27 February 2014

Academic Editor: Fabrizia Bamonti

Copyright © 2014 Luciana Morganti Ferreira Maselli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). Methods. PON1 activity was evaluated in 91 HIV-1 seronegative and 624 HIV-1 infected individuals (115 were not undergoing therapy (ART-naïve), and 509 were receiving HAART). HIV-1 infected individuals were treated with the following: efavirenz (EFV; ) or nevirapine (NVP; ) or lopinavir/ritonavir (LOP/r; ). Serum levels of total cholesterol (TC), HDL, and low-density lipoprotein (LDL) fractions and the atherogenic indices (AI, TC : HDL, and LDL : HDL ratios) were determined. Results. PON1 activity (U/L) was lower in the ART-naïve group compared with the other groups. PON1 activity correlated with CD4+ T-cell number of ART-naïve group ( ; ). The LOP/r group showed a reduction in HDL and an increase in AI (TC : HDL ratio) in comparison with other groups. Conclusion. PON1 activity was reduced in untreated individuals, but not in individuals receiving HAART. PON1 activity correlated with the number of CD4+ T-cells. The findings suggest that the activity of PON1 is associated with the immune status of HIV-1 infected individuals.