Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer: An Updated Meta-Analysis Involving 34,590 Subjects
Table 3
Meta-analysis of the association between COX-2 polymorphisms and breast cancer risk.
Comparisons
OR
95% CI
value
Heterogeneity
Effects model
value
B versus A
rs20417
1.04
0.98–1.10
0.17
56%
0.06
R
Caucasian
1.02
0.96–1.08
0.50
0%
0.92
F
Asian
1.45
1.15–1.84
0.002
0%
0.47
F
rs689466
0.99
0.94–1.04
0.69
33%
0.21
F
Caucasian
0.97
0.92–1.03
0.34
0%
0.58
F
Asian
1.14
0.97–1.33
—
—
—
—
rs5275
1.01
0.98–1.05
0.50
56%
0.01
R
Caucasian
1.00
0.97–1.04
0.80
41%
0.09
R
Asian
1.03
0.89–1.19
0.70
0%
0.51
F
BB versus AA
rs20417
1.21
1.02–1.42
0.03
0%
0.97
F
Caucasian
1.20
1.02–1.42
0.03
0%
0.92
F
Asian
1.54
0.49–4.78
0.46
0%
0.68
F
rs689466
1.01
0.88–1.15
0.93
22%
0.28
F
Caucasian
0.95
0.82–1.10
0.52
0%
0.69
F
Asian
1.31
0.95–1.80
—
—
—
—
rs5275
1.04
0.96–1.12
0.34
66%
0.0008
R
Caucasian
1.01
0.94–1.10
0.72
58%
0.01
R
Asian
1.26
0.85–1.85
0.25
7%
0.30
F
AB versus AA
rs20417
0.97
0.91–1.03
0.35
93%
<0.00001
R
Caucasian
0.94
0.88–1.01
0.07
95%
<0.00001
R
Asian
1.49
1.15–1.91
0.002
0%
0.53
F
rs689466
0.98
0.92–1.05
0.59
0%
0.59
F
Caucasian
0.97
0.91–1.04
0.44
0%
0.74
F
Asian
1.16
0.87–1.54
—
—
—
—
rs5275
0.99
0.95–1.04
0.81
0%
0.56
F
Caucasian
0.99
0.95–1.04
0.81
0%
0.47
F
Asian
0.96
0.80–1.14
0.96
0%
0.78
F
AB + BB versus AA
rs20417
1.01
0.96–1.08
0.64
54%
0.05
R
Caucasian
1.00
0.93–1.06
0.93
0%
0.84
F
Asian
1.49
1.16–1.91
0.002
0%
0.49
F
rs689466
0.90
0.87–0.95
0.0005
94%
<0.00001
R
Caucasian
0.88
0.83–0.94
<0.0001
96%
<0.00001
R
Asian
1.21
0.92–1.58
—
—
—
—
rs5275
1.02
0.98–1.07
0.33
62%
0.002
R
Caucasian
1.02
0.97–1.07
0.42
66%
0.002
R
Asian
0.99
0.84–1.17
0.92
0%
0.86
F
BB versus AA + AB
rs20417
1.22
1.03–1.43
0.02
0%
0.98
F
Caucasian
1.21
1.03–1.43
0.02
0%
0.94
F
Asian
146
0.47–4.56
0.51
0%
0.70
F
rs689466
1.01
0.89–1.15
0.85
0%
0.48
F
Caucasian
0.96
0.83–1.11
0.59
0%
0.76
F
Asian
1.18
0.92–1.51
—
—
—
—
rs5275
1.04
0.97–1.12
0.27
65%
0.0009
R
Caucasian
1.02
0.95–1.10
0.60
60%
0.01
R
Asian
1.28
0.87–1.87
0.21
15%
0.28
F
A: represents the major allele; B: represents the minor allele; F: fixed-effects model; R: random-effects model.
