Variability of the Transferrin Receptor 2 Gene in AMD
Table 4
Distribution of genotypes, frequency of alleles of the c.1892C>T polymorphism of the TFR2 gene, and odds ratios (OR) with 95% confidence intervals (95% CI) in age-related macular degeneration (AMD) patients and controls with respect to body mass index (BMI) (<26; 26–30; >30).
Genotype/allele c.1892C>T
BMI <26
Control (63) Number (%)
AMD (153) Number (%)
OR1) (95% CI)
CC
38 (0.6)
78 (0.51)
0.66 (0.36–1.21)
0.180
CT
20 (0.32)
55 (0.36)
1.19 (0.63–2.24)
0.588
TT
5 (0.08)
20 (0.13)
1.94 (0.69–5.49)
0.210
C
96 (0.76)
211 (0.69)
0.7 (0.45–1.1)
0.121
T
30 (0.24)
95 (0.31)
1.43 (0.91–2.25)
0.121
Genotype/allele c.1892C>T
BMI 26–30
Control (43) Number (%)
AMD (146) Number (%)
OR1) (95% CI)
CC
25 (0.58)
78 (0.53)
0.74 (0.37–1.51)
0.413
CT
13 (0.30)
55 (0.38)
1.66 (0.78–3.54)
0.192
TT
5 (0.12)
13 (0.09)
0.64 (0.2–1.98)
0.432
C
63 (0.73)
211 (0.72)
0.93 (0.54–1.59)
0.778
T
23 (0.27)
81 (0.28)
1.08 (0.63–1.86)
0.778
Genotype/allele c.1892C>T
BMI >30
Control (39) Number (%)
AMD (77) Number (%)
OR1) (95% CI)
CC
22 (0.56)
42 (0.55)
0.85 (0.38–1.87)
0.683
CT
10 (0.26)
32 (0.42)
2.32 (0.96–5.58)
0.061
TT
7 (0.18)
3 (0.04)
0.19 (0.04–0.78)↓
0.022
C
54 (0.69)
116 (0.75)
1.26 (0.7–2.29)
0.441
T
24 (0.31)
38 (0.25)
0.79 (0.44–1.44)
0.441
1)Adjusted for age and sex; ; data in boldface are statistically significant.