Research Article

Variability of the Transferrin Receptor 2 Gene in AMD

Table 4

Distribution of genotypes, frequency of alleles of the c.1892C>T polymorphism of the TFR2 gene, and odds ratios (OR) with 95% confidence intervals (95% CI) in age-related macular degeneration (AMD) patients and controls with respect to body mass index (BMI) (<26; 26–30; >30).

Genotype/allele c.1892C>TBMI <26
Control (63)
Number (%)
AMD (153)
Number (%)
OR1) (95% CI)

CC38 (0.6)78 (0.51)0.66 (0.36–1.21)0.180
CT20 (0.32)55 (0.36)1.19 (0.63–2.24)0.588
TT5 (0.08)20 (0.13)1.94 (0.69–5.49)0.210
C96 (0.76)211 (0.69)0.7 (0.45–1.1)0.121
T30 (0.24)95 (0.31)1.43 (0.91–2.25)0.121

Genotype/allele c.1892C>TBMI 26–30
Control (43)
Number (%)
AMD (146)
Number (%)
OR1) (95% CI)

CC25 (0.58)78 (0.53)0.74 (0.37–1.51)0.413
CT13 (0.30)55 (0.38)1.66 (0.78–3.54)0.192
TT5 (0.12)13 (0.09)0.64 (0.2–1.98)0.432
C63 (0.73)211 (0.72)0.93 (0.54–1.59)0.778
T23 (0.27)81 (0.28)1.08 (0.63–1.86)0.778

Genotype/allele c.1892C>TBMI >30
Control (39)
Number (%)
AMD (77)
Number (%)
OR1) (95% CI)

CC22 (0.56)42 (0.55)0.85 (0.38–1.87)0.683
CT10 (0.26)32 (0.42)2.32 (0.96–5.58)0.061
TT7 (0.18)3 (0.04)0.19 (0.040.78)0.022
C54 (0.69)116 (0.75)1.26 (0.7–2.29)0.441
T24 (0.31)38 (0.25)0.79 (0.44–1.44)0.441

1)Adjusted for age and sex; ; data in boldface are statistically significant.