Recipients with In Utero Induction of Tolerance Upregulated MHC Class I in the Engrafted Donor Skin

Figure 2

The expression of MHC related genes within engrafted C57BL/6 donor skins. MHC-I genes including 𝛽2m, H-2K𝛼, H-2D𝛼, and H-2L𝛼 were upregulated in engrafted donor skins (T) as compared with wild-type donor skins (W). However, the expressions of MHC class II (MHC-II) H-2A𝛼 and H-2A𝛽 in engrafted and wild-type C57BL/6 skins were comparable. MHC-II H-2E is nonfunctional in C57BL/6 mice and not tested. The means and their 95% confidence intervals are shown as horizontal lines and shade boxes, respectively.