MicroRNA-224 Suppresses Colorectal Cancer Cell Migration by Targeting Cdc42

Figure 2

Increased miR-224 expression suppressed the colorectal cancer (CRC) cell migration ability but not cell proliferation. (a) Normalized log₂ miR-224 expression data in CRC cell lines from the nondrug treated NCI-60 tumor cell line collection. (b) Real-time RT-PCR analysis of miR-224 expression levels in HT-29 and HCT-116 cells. (c) Real-time RT-PCR analysis of miR-224 expression levels in NCM- and 224 M-transfected HCT-116 cells. (d) Proliferation potential of NCM- and 224 M-transfected HCT-116 cells. (e, f) Migratory ability of NCM- and 224 M-transfected HCT-116 cells (*𝑃<0.05; **𝑃<0.01).

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