Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2014, Article ID 626185, 10 pages
http://dx.doi.org/10.1155/2014/626185
Review Article

Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis

1Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, Jiangsu Province 213003, China
2Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou 213003, China

Received 7 August 2014; Revised 29 September 2014; Accepted 30 September 2014; Published 23 October 2014

Academic Editor: Yi-Chia Huang

Copyright © 2014 Yingjie Shao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” A Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. V. N. Kim, J. Han, and M. C. Siomi, “Biogenesis of small RNAs in animals,” Nature Reviews Molecular Cell Biology, vol. 10, no. 2, pp. 126–139, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Selbach, B. Schwanhäusser, N. Thierfelder, Z. Fang, R. Khanin, and N. Rajewsky, “Widespread changes in protein synthesis induced by microRNAs,” Nature, vol. 455, no. 7209, pp. 58–63, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. R. C. Friedman, K. K. H. Farh, C. B. Burge, and D. P. Bartel, “Most mammalian mRNAs are conserved targets of microRNAs,” Genome Research, vol. 19, no. 1, pp. 92–105, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Garzon, M. Fabbri, A. Cimmino, G. A. Calin, and C. M. Croce, “MicroRNA expression and function in cancer,” Trends in Molecular Medicine, vol. 12, no. 12, pp. 580–587, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Di Leva and C. M. Croce, “MiRNA profiling of cancer,” Current Opinion in Genetics and Development, vol. 23, no. 1, pp. 3–11, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. M. N. Poy, L. Eliasson, J. Krutzfeldt et al., “A pancreatic islet-specific microRNA regulates insulin secretion,” Nature, vol. 432, no. 7014, pp. 226–230, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. N. N. Baroukh and E. van Obberghen, “Function of microRNA-375 and microRNA-124a in pancreas and brain,” FEBS Journal, vol. 276, no. 22, pp. 6509–6521, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. J.-W. Yan, J.-S. Lin, and X.-X. He, “The emerging role of miR-375 in cancer,” International Journal of Cancer, vol. 135, no. 5, pp. 1011–1018, 2014. View at Publisher · View at Google Scholar
  10. X.-X. He, Y. Chang, F.-Y. Meng et al., “MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo,” Oncogene, vol. 31, no. 28, pp. 3357–3369, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Ding, Y. Xu, W. Zhang et al., “MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2,” Cell Research, vol. 20, no. 7, pp. 784–793, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. E. A. Mathe, G. H. Nguyen, E. D. Bowman et al., “MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival,” Clinical Cancer Research, vol. 15, no. 19, pp. 6192–6200, 2009. View at Publisher · View at Google Scholar
  13. M. Avissar, B. C. Christensen, K. T. Kelsey, and C. J. Marsit, “MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma,” Clinical Cancer Research, vol. 15, no. 8, pp. 2850–2855, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Szczyrba, E. Nolte, S. Wach et al., “Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma,” Molecular Cancer Research, vol. 9, no. 6, pp. 791–800, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. P. D. S. Rocha Simonini, A. Breiling, N. Gupta et al., “Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor α in breast cancer cells,” Cancer Research, vol. 70, no. 22, pp. 9175–9184, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Yu, L. Jiang, C. Sun et al., “Decreased circulating miR-375: a potential biomarker for patients with non-small-cell lung cancer,” Gene, vol. 534, no. 1, pp. 60–65, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Wu, M. Li, C. Hu, and H. Duan, “Clinical significance of serum miR-223, miR-25 and miR-375 in patients with esophageal squamous cell carcinoma,” Molecular Biology Reports, vol. 41, no. 3, pp. 1257–1266, 2014. View at Publisher · View at Google Scholar
  18. Y. Li, Q. Jiang, N. Xia, H. Yang, and C. Hu, “Decreased expression of microRNA-375 in nonsmall cell lung cancer and its clinical significance,” The Journal of International Medical Research, vol. 40, no. 5, pp. 1662–1669, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Chang, H. Shi, C. Wang et al., “Correlation of microRNA-375 downregulation with unfavorable clinical outcome of patients with glioma,” Neuroscience Letters, vol. 531, no. 2, pp. 204–208, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Madhavan, M. Zucknick, M. Wallwiener et al., “Circulating miRNAs as surrogate markers for circulating tumor cells and prognostic markers in metastatic breast cancer,” Clinical Cancer Research, vol. 18, no. 21, pp. 5972–5982, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. M.-Z. Ma, X. Kong, M.-Z. Weng et al., “Candidate microRNA biomarkers of pancreatic ductal adenocarcinoma: meta-analysis, experimental validation and clinical significance,” Journal of Experimental and Clinical Cancer Research, vol. 32, no. 1, article 71, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. G. H. Nguyen, A. J. Schetter, D. B. Chou et al., “Inflammatory and microRNA gene expression as prognostic classifier of Barrett's-associated esophageal adenocarcinoma,” Clinical Cancer Research, vol. 16, no. 23, pp. 5824–5834, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. K. L. Kong, D. L. W. Kwong, T. H.-M. Chan et al., “MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor,” Gut, vol. 61, no. 1, pp. 33–42, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Li, X. Li, Y. Li et al., “Cell-specific detection of miR-375 downregulation for predicting the prognosis of esophageal squamous cell carcinoma by miRNA in situ hybridization,” PLoS ONE, vol. 8, no. 1, Article ID e53582, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Komatsu, D. Ichikawa, H. Takeshita et al., “Prognostic impact of circulating miR-21 and miR-375 in plasma of patients with esophageal squamous cell carcinoma,” Expert Opinion on Biological Therapy, vol. 12, no. 1, pp. S53–S59, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. X. Zhang, Z. Yan, J. Zhang et al., “Combination of hsa-miR-375 and hsa-miR-142-5p as a predictor for recurrence risk in gastric cancer patients following surgical resection,” Annals of Oncology, vol. 22, no. 10, pp. 2257–2266, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Harris, L. Jimenez, N. Kawachi et al., “Low-level expression of miR-375 correlates with poor outcome and metastasis while altering the invasive properties of head and neck squamous cell carcinomas,” American Journal of Pathology, vol. 180, no. 3, pp. 917–928, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Jonsdottir, S. R. Janssen, F. C. Da Rosa et al., “Validation of expression patterns for nine miRNAs in 204 lymph-node negative breast cancers,” PLoS ONE, vol. 7, no. 11, Article ID e48692, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. A. L. Carlsen, M. T. Joergensen, S. Knudsen, O. B. S. De Muckadell, and N. H. H. Heegaard, “Cell-free plasma microRNA in pancreatic ductal adenocarcinoma and disease controls,” Pancreas, vol. 42, no. 7, pp. 1107–1113, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. R. J. Bryant, T. Pawlowski, J. W. F. Catto et al., “Changes in circulating microRNA levels associated with prostate cancer,” British Journal of Cancer, vol. 106, no. 4, pp. 768–774, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. D. F. Stroup, J. A. Berlin, S. C. Morton et al., “Meta-analysis of observational studies in epidemiology: a proposal for reporting,” Journal of the American Medical Association, vol. 283, no. 15, pp. 2008–2012, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Stang, “Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses,” European Journal of Epidemiology, vol. 25, no. 9, pp. 603–605, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. J. F. Tierney, L. A. Stewart, D. Ghersi, S. Burdett, and M. R. Sydes, “Practical methods for incorporating summary time-to-event data into meta-analysis,” Trials, vol. 8, article 16, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. J. P. T. Higgins and S. G. Thompson, “Quantifying heterogeneity in a meta-analysis,” Statistics in Medicine, vol. 21, no. 11, pp. 1539–1558, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. J. P. T. Higgins, S. G. Thompson, J. J. Deeks, and D. G. Altman, “Measuring inconsistency in meta-analyses,” British Medical Journal, vol. 327, no. 7414, pp. 557–560, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Duval and R. Tweedie, “Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis,” Biometrics, vol. 56, no. 2, pp. 455–463, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. N. Nohata, T. Hanazawa, N. Kikkawa et al., “Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC),” Journal of Human Genetics, vol. 56, no. 8, pp. 595–601, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. A. B. Y. Hui, J. P. Bruce, N. M. Alajez et al., “Significance of dysregulated metadherin and microRNA-375 in head and neck cancer,” Clinical Cancer Research, vol. 17, no. 24, pp. 7539–7550, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Tsukamoto, C. Nakada, T. Noguchi et al., “MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3ζ,” Cancer Research, vol. 70, no. 6, pp. 2339–2349, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. X. Li, R. Lin, and J. Li, “Epigenetic silencing of MicroRNA-375 regulates PDK1 expression in esophageal cancer,” Digestive Diseases and Sciences, vol. 56, no. 10, pp. 2849–2856, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Wach, E. Nolte, J. Szczyrba et al., “MicroRNA profiles of prostate carcinoma detected by multiplatform microRNA screening,” International Journal of Cancer, vol. 130, no. 3, pp. 611–621, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. L. A. Selth, S. Townley, J. L. Gillis et al., “Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease,” International Journal of Cancer, vol. 131, no. 3, pp. 652–661, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. O. Giricz, P. A. Reynolds, A. Ramnauth et al., “Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity,” Journal of Pathology, vol. 226, no. 1, pp. 108–119, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. A. Ward, A. Balwierz, J. D. Zhang et al., “Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer,” Oncogene, vol. 32, no. 9, pp. 1173–1182, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. T. Kinoshita, N. Nohata, H. Yoshino et al., “Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma,” International Journal of Oncology, vol. 40, no. 1, pp. 185–193, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Luo, J. Wu, Z. Li et al., “miR-375 suppresses IGF1R expression and contributes to inhibition of cell progression in laryngeal squamous cell carcinoma,” BioMed Research International, vol. 2014, Article ID 374598, 11 pages, 2014. View at Publisher · View at Google Scholar
  47. Y. Xu, J. Jin, Y. Liu et al., “Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2,” PLoS ONE, vol. 9, no. 7, Article ID e99516, 2014. View at Google Scholar
  48. Z.-Y. Shen, Z.-Z. Zhang, H. Liu, E.-H. Zhao, and H. Cao, “miR-375 inhibits the proliferation of gastric cancer cells by repressing ERBB2 expression,” Experimental and Therapeutic Medicine, vol. 7, no. 6, pp. 1757–1761, 2014. View at Publisher · View at Google Scholar · View at Scopus
  49. L. Miao, K. Liu, M. Xie, Y. Xing, and T. Xi, “miR-375 inhibits Helicobacter pylori-induced gastric carcinogenesis by blocking JAK2-STAT3 signaling,” Cancer Immunology, Immunotherapy, vol. 63, no. 7, pp. 699–711, 2014. View at Publisher · View at Google Scholar · View at Scopus
  50. Y. Chang, W. Yan, X. He et al., “MiR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions,” Gastroenterology, vol. 143, no. 1, pp. 177–187, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. A. M. Liu, R. T. P. Poon, and J. M. Luk, “MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties,” Biochemical and Biophysical Research Communications, vol. 394, no. 3, pp. 623–627, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. M. Furuta, K.-I. Kozaki, S. Tanaka, S. Arii, I. Imoto, and J. Inazawa, “miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma,” Carcinogenesis, vol. 31, no. 5, pp. 766–776, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. E. Nishikawa, H. Osada, Y. Okazaki et al., “MiR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer,” Cancer Research, vol. 71, no. 19, pp. 6165–6173, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. S. Yoda, K. Soejima, J. Hamamoto et al., “Claudin-1 is a novel target of miR-375 in non-small-cell lung cancer,” Lung Cancer, vol. 85, no. 3, pp. 366–372, 2014. View at Google Scholar
  55. J. Zhou, S. Song, S. He et al., “MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway,” International Journal of Molecular Medicine, vol. 33, no. 4, pp. 950–956, 2014. View at Publisher · View at Google Scholar · View at Scopus
  56. J. L. Eun, Y. Gusev, J. Jiang et al., “Expression profiling identifies microRNA signature in pancreatic cancer,” International Journal of Cancer, vol. 120, no. 5, pp. 1046–1054, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. Y. Wang, Q. Tang, M. Li, S. Jiang, and X. Wang, “MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA,” Biochemical and Biophysical Research Communications, vol. 444, no. 2, pp. 199–204, 2014. View at Publisher · View at Google Scholar · View at Scopus
  58. P. Faltejskova, M. Svoboda, K. Srutova et al., “Identification and functional screening of microRNAs highly deregulated in colorectal cancer,” Journal of Cellular and Molecular Medicine, vol. 16, no. 11, pp. 2655–2666, 2012. View at Publisher · View at Google Scholar · View at Scopus
  59. F. Wang, Y. Li, J. Zhou et al., “MiR-375 is down-regulated in squamous cervical cancer and inhibits cell migration and invasion via targeting transcription factor SP1,” The American Journal of Pathology, vol. 179, no. 5, pp. 2580–2588, 2011. View at Publisher · View at Google Scholar · View at Scopus
  60. S. M. Wilting, W. Verlaat, A. Jaspers et al., “Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis,” Epigenetics, vol. 8, no. 2, pp. 220–228, 2013. View at Publisher · View at Google Scholar · View at Scopus
  61. X.-M. Ye, H.-Y. Zhu, W.-D. Bai et al., “Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R,” BMC Cancer, vol. 14, no. 1, article 134, 2014. View at Publisher · View at Google Scholar · View at Scopus