Disease Markers

Review Article

Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis

Table 3

The dysregulated expression and target genes or pathways of miR-375 in cancer.
Type of cancermiR-375 expressionValidated target genes or pathwaysReference
HNSCCDownMTDH, LDHB, IGF1R[37, 38, 45, 46]
ESCCDownPDK1, IGF1R[23, 40]
Gastric cancerDownJAK2-STAT3, PDK1, YWHAZ, ERBB2[11, 39, 47–49]
HCCDownAEG-1, ATG7, YAP1[10, 50–52]
Lung cancerDownYAP1, CLDN1[53, 54]
Pancreatic cancerDownPDK1[55, 56]
Colorectal cancerDownPIK3CA[57, 58]
Cervical cancerDownSP1[59, 60]
Breast cancerUpRASD1, IGF1R[15, 61]
Prostate cancerUpSec23A[14]
HNSCC: head and neck squamous cell carcinomas; ESCC: esophageal squamous cell carcinoma; HCC: hepatocellular carcinoma.