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Disease Markers
Volume 2014 (2014), Article ID 690853, 6 pages
Research Article

Serum Interleukin 17 Levels in Patients with Crohn’s Disease: Real Life Data

1Department of Gastroenterology, Elazig Education and Research Hospital, Rizaiye Mah. Inonu Caddesi, 23200 Elazig, Turkey
2Gastroenterology Department, Turkiye Gazetesi Hospital, 34381 Istanbul, Turkey
3Department of Gastroenterology, Ankara Oncology Education and Research Hospital, 06500 Ankara, Turkey
4Department of Gastroenterology, Batman State Hospital, 72070 Batman, Turkey
5Department of Genetics and Bioengineering, Yeditepe University, 34755 Istanbul, Turkey
6Department of Gastroenterology, Umraniye Training and Research Hospital, 34764 Istanbul, Turkey

Received 3 June 2014; Accepted 16 June 2014; Published 16 July 2014

Academic Editor: Giuseppe Murdaca

Copyright © 2014 Abdurrahman Sahin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to investigate serum IL17 levels in patients with Crohn’s disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. Methods. Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels, complete blood count, blood chemistry, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured, and Crohn’s disease activity was calculated using Crohn’s disease activity index (CDAI). Results. The mean serum IL17 level of CD patients did not differ from those of healthy controls (). There was no difference between the mean serum IL levels of active CD patients and of quiescent CD patients (). However, the mean IL17 level of active patients was lower than of control subjects (). Serum IL17 was not correlated with inflammatory markers (ESR, CRP, white blood count, platelet count, and albumin) and CDAI. Conclusions. Peripheral blood serum IL17 levels of CD patients were not higher than of healthy controls, and also, serum IL17 level was not correlated with clinical disease activity. Peripheral IL17 measurement is not a useful tool for detecting and monitoring Crohn’s disease which is understood to have complex etiopathogenesis.