A Disease Modification Effect of APOE E4 on the Association between Urinary Albumin Excretion and Cognition in Korean Adults
Table 4
Adjusted mean (±SE) scores of K-mMMSE and cognitive domains according to categories of UACR in APOE E4 carriers.
K-mMMSE and cognitive domain scores according to UACR (mg/g)
for overall
for linear
Partial eta-squared, %
<15.0
15.0–29.9
30.0–299.9
≥300.0
difference
trend
Number
852
402
421
23
Global
K-mMMSE (100)
78.2 ± 0.4
75.3 ± 0.6
77.0 ± 0.6
70.0 ± 2.6
<0.001
0.007
1.6
Domains
Attention (7)
3.6 ± 0.1
3.5 ± 0.1
3.7 ± 0.1
3.0 ± 0.4
0.236
0.891
0.3
Memory (26)
21.2 ± 0.2
19.5 ± 0.2
20.5 ± 0.2
19.4 ± 1.0
<0.001
0.003
2.2
Orientation (20)
18.6 ± 0.1
18.2 ± 0.2
18.2 ± 0.2
16.3 ± 0.7
0.002
0.003
1.1
Visuospatial (10)
8.1 ± 0.1
7.8 ± 0.1
8.2 ± 0.1
7.3 ± 0.5
0.022
0.823
0.7
Language (18)
15.1 ± 0.1
15.0 ± 0.1
14.9 ± 0.1
13.4 ± 0.6
0.029
0.079
0.7
Frontoexecutive (19)
11.8 ± 0.1
11.5 ± 0.2
11.5 ± 0.2
10.2 ± 0.7
0.107
0.083
0.5
Data are expressed as mean ± standard error. The numbers in the brackets following domain names represent the total (maximum) score. Adjusted for age, sex, educational attainments, smoking status, alcohol use, BMI, eGFR, hypertension, type 2 diabetes, hyperlipidemia, and CES-DK.
