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Disease Markers
Volume 2014, Article ID 725731, 6 pages
Research Article

Association of Tagging SNPs in the MTHFR Gene with Risk of Type 2 Diabetes Mellitus and Serum Homocysteine Levels in a Chinese Population

1Undergraduate Student Brigade 11 Battalion, Third Military Medical University, Chongqing 400038, China
2Center for Reproductive Medicine, The First Affiliated Hospital of Jilin University, Changchun 130062, China
3Laboratory of Immune, People’s Hospital of Linyi, No. 27 Eastern Jiefang Road, Lanshan, Linyi 276003, China

Received 17 June 2014; Revised 22 July 2014; Accepted 24 July 2014; Published 6 August 2014

Academic Editor: Seul-Ki Jeong

Copyright © 2014 Han Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Yuelong Ji, Xiangyi Kong, Guoying Wang, Xiumei Hong, Xin Xu, Zhu Chen, Tami Bartell, Xiping Xu, Genfu Tang, Fanfan Hou, Yong Huo, Xiaobin Wang, and Binyan Wang, “Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan,” Nutrients, vol. 6, no. 12, pp. 5900–5914, 2014. View at Publisher · View at Google Scholar
  • Pamella Kelly Farias de Aguiar, Ricardo D. Coletta, Allane Maria Lacerda Ferreira de Oliveira, Renato Assis Machado, Paulo Germano Cavalcante Furtado, Lindalva Alves de Oliveira, Sibele Nascimento de Aquino, Hercilio Martelli-Junior, Silvia Regina de Almeida Reis, Helenara Salvati Bertolossi Moreira, and Darlene Camati Persuhn, “ rs1801133C>T polymorphism in MTHFR is a risk factor for nonsyndromic cleft lip with or without cleft palate in the Brazilian population ,” Birth Defects Research Part A: Clinical and Molecular Teratology, 2015. View at Publisher · View at Google Scholar
  • Xingxing Ren, Zeng. ai Chen, Shuang Zheng, Tingting Han, Yangxue Li, Wei Liu, and Yaomin Hu, “Association between Triglyceride to HDL-C Ratio (TG/HDL-C) and Insulin Resistance in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus,” Plos One, vol. 11, no. 4, 2016. View at Publisher · View at Google Scholar
  • Xueyuan Zhi, Boyi Yang, Shujun Fan, Yongfang Li, Miao He, Da Wang, Yanxun Wang, Jian Wei, Quanmei Zheng, and Guifan Sun, “Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes,” International Journal of Environmental Research and Public Health, vol. 13, no. 12, pp. 1243, 2016. View at Publisher · View at Google Scholar
  • Hudiakova, Pchelin, Shishkin, Smirnov, Ivanov, Makarenko, Bayrasheva, and Staroselsky, “Hyperhomocysteinemia in men with metabolic syndrome and early stages of chronic kidney disease,” Arterial Hypertension (Russian Federation), vol. 23, no. 2, pp. 141–149, 2017. View at Publisher · View at Google Scholar
  • Nithya, Isabel, Angeline, Priscilla, and Asirvatham, “Association of MTHFR A1298C gene variant, dna damage, and total antioxidant status with the risk of type 2 diabetes mellitus and its complications,” Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 6, pp. 344–348, 2018. View at Publisher · View at Google Scholar
  • Jie V. Zhao, C. Mary Schooling, and Jia Xi Zhao, “The effects of folate supplementation on glucose metabolism and risk of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials,” Annals of Epidemiology, 2018. View at Publisher · View at Google Scholar
  • Yanzi Meng, Xiaoling Liu, Kai Ma, Lili Zhang, Mao Lu, Minsu Zhao, Min‐Xin Guan, and Guijun Qin, “ Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility ,” Molecular Genetics & Genomic Medicine, 2019. View at Publisher · View at Google Scholar