Research Article
Association of Tagging SNPs in the MTHFR Gene with Risk of Type 2 Diabetes Mellitus and Serum Homocysteine Levels in a Chinese Population
Table 2
ORs and 95% CIs for T2DM in relation to polymorphisms of MTHFR gene.
| | SNP | Genotypes | Cases, (%) | Controls, (%) | OR (95% CI)* | OR (95% CI)† | trend‡ |
| | rs12121543 | CC | 402 (67.7) | 462 (67.9) | 1.00 | 1.00 | 0.79 | | CA | 177 (29.8) | 194 (28.5) | 1.04 (0.82–1.33) | 1.07 (0.83–1.38) | | AA | 15 (2.5) | 24 (3.5) | 0.71 (0.37–1.37) | 0.77 (0.38–1.54) | | CA + AA | 192 (32.3) | 218 (32.1) | 1.01 (0.80–1.27) | 1.04 (0.81–1.33) |
| | rs13306561 | TT | 474 (79.8) | 543 (79.8) | 1.00 | 1.00 | 0.98 | | TC | 116 (19.5) | 131 (19.3) | 1.01 (0.76–1.33) | 1.04 (0.77–1.39) | | CC | 4 (0.7) | 6 (0.9) | 0.73 (0.20–2.61) | 0.58 (0.15–2.21) | | TC + CC | 120 (20.2) | 137 (20.1) | 1.00 (0.76–1.31) | 1.01 (0.76–1.35) |
| | rs13306553 | TT | 480 (80.8) | 547 (80.4) | 1.00 | 1.00 | 0.82 | | TC | 110 (18.5) | 129 (19.0) | 0.97 (0.73–1.28) | 0.97 (0.72–1.30) | | CC | 4 (0.7) | 4 (0.6) | 1.08 (0.27–4.36) | 1.06 (0.25–4.50) | | TC + CC | 114 (19.2) | 133 (19.6) | 0.97 (0.73–1.28) | 0.97 (0.73–1.30) |
| | rs9651118 | TT | 303 (51.0) | 288 (42.4) | 1.00 | 1.00 | 0.009 | | TC | 231 (38.9) | 300 (44.1) | 0.73 (0.58–0.93) | 0.72 (0.56–0.93) | | CC | 60 (10.1) | 92 (13.5) | 0.62 (0.43–0.90) | 0.59 (0.40–0.87) | | TC + CC | 291 (49.0) | 392 (57.6) | 0.71 (0.57–0.88) | 0.69 (0.55–0.87) |
| | rs1801133 | CC | 234 (39.5) | 298 (43.8) | 1.00 | 1.00 | 0.14 | | CT | 293 (49.4) | 312 (45.9) | 1.20 (0.95–1.51) | 1.22 (0.96–1.56) | | TT | 66 (11.1) | 70 (10.3) | 1.22 (0.83–1.77) | 1.23 (0.83–1.84) | | CT + TT | 359 (60.5) | 382 (56.2) | 1.20 (0.96–1.50) | 1.22 (0.97–1.55) |
| | rs2274976 | GG | 484 (81.5) | 554 (81.5) | 1.00 | 1.00 | 0.99 | | GA | 105 (17.7) | 119 (17.5) | 1.00 (0.75–1.34) | 1.02 (0.75–1.38) | | AA | 5 (0.8) | 7 (1.0) | 0.78 (0.25–2.49) | 0.62 (0.19–2.04) | | GA + AA | 110 (18.5) | 126 (18.5) | 0.99 (0.75–1.32) | 1.00 (0.74–1.34) |
| | rs4846048 | AA | 490 (82.5) | 560 (82.3) | 1.00 | 1.00 | 0.95 | | AG | 99 (16.7) | 114 (16.8) | 0.99 (0.74–1.33) | 1.01 (0.74–1.38) | | GG | 5 (0.8) | 6 (0.9) | 0.97 (0.29–3.19) | 1.39 (0.40–4.88) | | AG + GG | 104 (17.5) | 120 (17.6) | 0.99 (0.74–1.32) | 1.03 (0.76–1.39) |
| | rs1801131 | AA | 370 (62.3) | 455 (66.9) | 1.00 | 1.00 | 0.04 | | AC | 208 (35.0) | 197 (29.0) | 1.29 (1.02–1.64) | 1.32 (1.03–1.70) | | CC | 16 (2.7) | 28 (4.1) | 0.69 (0.37–1.30) | 0.74 (0.38–1.44) | | AC + CC | 224 (37.7) | 225 (33.1) | 1.22 (0.97–1.54) | 1.25 (0.98–1.59) |
| | rs17037396 | CC | 456 (76.8) | 521 (76.5) | 1.00 | 1.00 | 0.88 | | CT | 126 (21.2) | 147 (21.6) | 0.98 (0.75–1.28) | 1.03 (0.78–1.37) | | TT | 12 (2.0) | 13 (1.9) | 1.07 (0.48–2.36) | 0.93 (0.41–2.11) | | CT + TT | 138 (23.2) | 160 (23.5) | 0.98 (0.76–1.28) | 1.02 (0.78–1.34) |
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Adjusted for age. †Adjusted for age, sex, BMI, and hypertension.
‡Test of trend for the number of copies of the variant allele (0, 1, and 2).
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