Table 2: ORs and 95% CIs for T2DM in relation to polymorphisms of MTHFR gene.

SNPGenotypesCases, (%)Controls, (%)OR (95% CI)*OR (95% CI) trend

rs12121543CC402 (67.7)462 (67.9)1.001.000.79
CA177 (29.8)194 (28.5)1.04 (0.82–1.33)1.07 (0.83–1.38)
AA15 (2.5)24 (3.5)0.71 (0.37–1.37)0.77 (0.38–1.54)
CA + AA192 (32.3)218 (32.1)1.01 (0.80–1.27)1.04 (0.81–1.33)

rs13306561TT474 (79.8)543 (79.8)1.001.000.98
TC116 (19.5)131 (19.3)1.01 (0.76–1.33)1.04 (0.77–1.39)
CC4 (0.7)6 (0.9)0.73 (0.20–2.61)0.58 (0.15–2.21)
TC + CC120 (20.2)137 (20.1)1.00 (0.76–1.31)1.01 (0.76–1.35)

rs13306553TT480 (80.8)547 (80.4)1.001.000.82
TC110 (18.5)129 (19.0)0.97 (0.73–1.28)0.97 (0.72–1.30)
CC4 (0.7)4 (0.6)1.08 (0.27–4.36)1.06 (0.25–4.50)
TC + CC114 (19.2)133 (19.6)0.97 (0.73–1.28)0.97 (0.73–1.30)

rs9651118TT303 (51.0)288 (42.4)1.001.000.009
TC231 (38.9)300 (44.1)0.73 (0.58–0.93)0.72 (0.56–0.93)
CC60 (10.1)92 (13.5)0.62 (0.43–0.90)0.59 (0.40–0.87)
TC + CC291 (49.0)392 (57.6)0.71 (0.57–0.88)0.69 (0.55–0.87)

rs1801133CC234 (39.5)298 (43.8)1.001.000.14
CT293 (49.4)312 (45.9)1.20 (0.95–1.51)1.22 (0.96–1.56)
TT66 (11.1)70 (10.3)1.22 (0.83–1.77)1.23 (0.83–1.84)
CT + TT359 (60.5)382 (56.2)1.20 (0.96–1.50)1.22 (0.97–1.55)

rs2274976GG484 (81.5)554 (81.5)1.001.000.99
GA105 (17.7)119 (17.5)1.00 (0.75–1.34)1.02 (0.75–1.38)
AA5 (0.8)7 (1.0)0.78 (0.25–2.49)0.62 (0.19–2.04)
GA + AA110 (18.5)126 (18.5)0.99 (0.75–1.32)1.00 (0.74–1.34)

rs4846048AA490 (82.5)560 (82.3)1.001.000.95
AG99 (16.7)114 (16.8)0.99 (0.74–1.33)1.01 (0.74–1.38)
GG5 (0.8)6 (0.9)0.97 (0.29–3.19)1.39 (0.40–4.88)
AG + GG104 (17.5)120 (17.6)0.99 (0.74–1.32)1.03 (0.76–1.39)

rs1801131AA370 (62.3)455 (66.9)1.001.000.04
AC208 (35.0)197 (29.0)1.29 (1.02–1.64)1.32 (1.03–1.70)
CC16 (2.7)28 (4.1)0.69 (0.37–1.30)0.74 (0.38–1.44)
AC + CC224 (37.7)225 (33.1)1.22 (0.97–1.54)1.25 (0.98–1.59)

rs17037396CC456 (76.8)521 (76.5)1.001.000.88
CT126 (21.2)147 (21.6)0.98 (0.75–1.28)1.03 (0.78–1.37)
TT12 (2.0)13 (1.9)1.07 (0.48–2.36)0.93 (0.41–2.11)
CT + TT138 (23.2)160 (23.5)0.98 (0.76–1.28)1.02 (0.78–1.34)

Adjusted for age. Adjusted for age, sex, BMI, and hypertension.
Test of trend for the number of copies of the variant allele (0, 1, and 2).