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Disease Markers
Volume 2014, Article ID 786543, 8 pages
http://dx.doi.org/10.1155/2014/786543
Research Article

Hypertrophy of Ligamentum Flavum in Lumbar Spine Stenosis Is Associated with Increased miR-155 Level

1Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 1630 Dongfang Road, Shanghai 200127, China
2Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China

Received 23 December 2013; Revised 16 March 2014; Accepted 13 April 2014; Published 18 May 2014

Academic Editor: Dinesh Kumbhare

Copyright © 2014 Jianwei Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Englund, “Lumbar spinal stenosis,” Current Sports Medicine Reports, vol. 6, no. 1, pp. 50–55, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. A. A. Safak, M. Is, O. Sevinc et al., “The thickness of the ligamentum flavum in relation to age and gender,” Clinical Anatomy, vol. 23, no. 1, pp. 79–83, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Abbas, K. Hamoud, Y. M. Masharawi et al., “Ligamentum flavum thickness in normal and stenotic lumbar spines,” Spine, vol. 35, no. 12, pp. 1225–1230, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Szpalski and R. Gunzburg, “Lumbar spinal stenosis in the elderly: an overview,” European Spine Journal, vol. 12, supplement 2, pp. S170–S175, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Viejo-Fuertes, D. Liguoro, J. Rivel, D. Midy, and J. Guerin, “Morphologic and histologic study of the ligamentum flavum in the thoraco-lumbar region,” Surgical and Radiologic Anatomy, vol. 20, no. 3, pp. 171–176, 1998. View at Google Scholar · View at Scopus
  6. H. Kosaka, K. Sairyo, A. Biyani et al., “Pathomechanism of loss of elasticity and hypertrophy of lumbar ligamentum flavum in elderly patients with lumbar spinal canal stenosis,” Spine, vol. 32, no. 25, pp. 2805–2811, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. P. K. Schräder, D. Grob, B. A. Rahn, J. Cordey, and J. Dvorak, “Histology of the ligamentum flavum in patients with degenerative lumbar spinal stenosis,” European Spine Journal, vol. 8, no. 4, pp. 323–328, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. I.-S. Oh and K.-Y. Ha, “Matrix metalloproteinase-3 on ligamentum flavum in degenerative lumbar spondylolisthesis,” Spine, vol. 34, no. 16, pp. E552–E557, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Cui, K. Watanabe, Y. Miyauchi et al., “Matrix metalloproteinase 13 in the ligamentum flavum from lumbar spinal canal stenosis patients with and without diabetes mellitus,” Journal of Orthopaedic Science, vol. 16, no. 6, pp. 785–790, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. J.-B. Park, C.-G. Kong, K.-H. Suhl, E.-D. Chang, and K. D. Riew, “The increased expression of matrix metalloproteinases associated with elastin degradation and fibrosis of the ligamentum flavum in patients with lumbar spinal stenosis,” Clinics in Orthopedic Surgery, vol. 1, no. 2, pp. 81–89, 2009. View at Google Scholar · View at Scopus
  11. J.-B. Park, J.-K. Lee, S.-J. Park, and K. D. Riew, “Hypertrophy of ligamentum flavum in lumbar spinal stenosis associated with increased proteinase inhibitor concentration,” Journal of Bone and Joint Surgery A, vol. 87, no. 12 I, pp. 2750–2757, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Zhang, J. Chen, Z.-M. Zhong, D. Yang, and Q. Zhu, “Is platelet-derived growth factor-BB expression proportional to fibrosis in the hypertrophied lumber ligamentum flavum?” Spine, vol. 35, no. 25, pp. E1479–1486, 2010. View at Google Scholar · View at Scopus
  13. Z.-M. Zhong, D.-S. Zha, W.-D. Xiao et al., “Hypertrophy of ligamentum flavum in lumbar spine stenosis associated with the increased expression of connective tissue growth factor,” Journal of Orthopaedic Research, vol. 29, no. 10, pp. 1592–1597, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Shafaq, A. Suzuki, H. Terai, S. Wakitani, and H. Nakamura, “Cellularity and cartilage matrix increased in hypertrophied ligamentum flavum: histopathological analysis focusing on the mechanical stress and bone morphogenetic protein signaling,” Journal of Spinal Disorders and Techniques, vol. 25, no. 2, pp. 107–115, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Löhr, J. A. Hampl, J. Y. Lee, R.-I. Ernestus, M. Deckert, and W. Stenzel, “Hypertrophy of the lumbar ligamentum flavum is associated with inflammation-related TGF-β expression,” Acta Neurochirurgica, vol. 153, no. 1, pp. 134–141, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Sairyo, A. Biyani, V. K. Goel et al., “Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation-related scar tissue,” Spine, vol. 32, no. 11, pp. E340–E347, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Sairyo, A. Biyani, V. Goel et al., “Pathomechanism of ligamentum flavum hypertrophy: a multidisciplinary investigation based on clinical, biomechanical, histologic, and biologic assessments,” Spine, vol. 30, no. 23, pp. 2649–2656, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. D. P. Bartel, “MicroRNAs: genomics, biogenesis, mechanism, and function,” Cell, vol. 116, no. 2, pp. 281–297, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. H.-Q. Wang, X.-D. Yu, Z.-H. Liu et al., “Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3,” Journal of Pathology, vol. 225, no. 2, pp. 232–242, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. X. Jiang, E. Tsitsiou, S. E. Herrick, and M. A. Lindsay, “MicroRNAs and the regulation of fibrosis,” FEBS Journal, vol. 277, no. 9, pp. 2015–2021, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. K. V. Pandit, J. Milosevic, and N. Kaminski, “MicroRNAs in idiopathic pulmonary fibrosis,” Translational Research, vol. 157, no. 4, pp. 191–199, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Tardif, D. Hum, J.-P. Pelletier, N. Duval, and J. Martel-Pelletier, “Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes,” BMC Musculoskeletal Disorders, vol. 10, no. 1, article 148, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Miyaki, T. Nakasa, S. Otsuki et al., “MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses,” Arthritis and Rheumatism, vol. 60, no. 9, pp. 2723–2730, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Stanczyk, D. M. Leslie Pedrioli, F. Brentano et al., “Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis,” Arthritis and Rheumatism, vol. 58, no. 4, pp. 1001–1009, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. J. He, F. Zhang, Y. Wu et al., “Prognostic role of microRNA-155 in various carcinomas: results from a meta-analysis,” Disease Markers, vol. 34, pp. 379–386, 2013. View at Publisher · View at Google Scholar
  26. G. Wang, B. C.-H. Kwan, F. M.-M. Lai, K.-M. Chow, P. K.-T. Li, and C.-C. Szeto, “Elevated levels of miR-146a and miR-155 in kidney biopsy and urine from patients with IgA nephropathy,” Disease Markers, vol. 30, no. 4, pp. 171–179, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Sakamaki, K. Sairyo, T. Sakai, T. Tamura, Y. Okada, and H. Mikami, “Measurements of ligamentum flavum thickening at lumbar spine using MRI,” Archives of Orthopaedic and Trauma Surgery, vol. 129, no. 10, pp. 1415–1419, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Benoist, “Natural history of the aging spine,” European Spine Journal, vol. 12, no. 2, pp. S86–S89, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Okuda, I. Baba, Y. Fujimoto et al., “The pathology of ligamentum flavum in degenerative lumbar disease,” Spine, vol. 29, no. 15, pp. 1689–1697, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Bala and G. Szabo, “MicroRNA signature in alcoholic liver disease,” International Journal of Hepatology, vol. 2012, Article ID 498232, 6 pages, 2012. View at Publisher · View at Google Scholar
  31. I. P. Pogribny, A. Starlard-Davenport, V. P. Tryndyak et al., “Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice,” Laboratory Investigation, vol. 90, no. 10, pp. 1437–1446, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Bhattacharyya, N. S. Balakathiresan, C. Dalgard et al., “Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8,” Journal of Biological Chemistry, vol. 286, no. 13, pp. 11604–11615, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. W. Kong, H. Yang, L. He et al., “MicroRNA-155 is regulated by the transforming growth factor β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA,” Molecular and Cellular Biology, vol. 28, no. 22, pp. 6773–6784, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. D. Rai, S.-W. Kim, M. R. McKeller, P. L. M. Dahia, and R. C. T. Aguiar, “Targeting of SMAD5 links microRNA-155 to the TGF-β pathway and lymphomagenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 7, pp. 3111–3116, 2010. View at Publisher · View at Google Scholar · View at Scopus