High Frequency of CD8 Positive Lymphocyte Infiltration Correlates with Lack of Lymph Node Involvement in Early Rectal Cancer
Table 3
Logistic regression analysis for the prediction of lymph node involvement in ERC.
Univariate
Multivariate
OR (95% CI)
values
OR (95% CI)
values
CD8
0.994 (0.992–0.996)
0.009
0.996 (0.994–0.998)
0.025
TIA-1
0.988 (0.984–0.994)
0.047
—
—
Age
0.998 (0.995–1.00)
0.696
—
—
Gender (m. versus f.)
1.066 (0.989–1.151)
0.391
—
—
pT stage (1, 2)
1.199 (1.090–1.318)
0.058
—
—
Tumor grade (1, 2, 3)
1.415 (1.242–1.612)
0.009
1.434 (1.264–1.627)
0.005
Vascular invasion
1.641 (1.473–1.828)
<0.0001
1.465 (1.319–1.628)
0.0005
Tumor border configuration
1.24 (1.151–1.336)
0.005
1.254 (1.169–1.344)
0.001
Microsatellite stability (deficient versus proficient)
1.276 (1.083–1.502)
0.14
—
—
Uni- and multivariate logistic regression analyses showing OR and values for all ERCs (, less than 126 due to missing values) conferred by CD8 and TIA-1 density, age, sex, tumor size, tumor grade, vascular invasion, tumor border configuration, and microsatellite stability.
