Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2014 (2014), Article ID 793646, 6 pages
http://dx.doi.org/10.1155/2014/793646
Research Article

The Role of Haptoglobin Genotypes in Chagas Disease

Laboratorio de Fisiopatología, Centro de Medicina Experimental “Miguel Layrisse”, Instituto Venezolano de Investigaciones Científicas, Kilómetro 11 Carretera Panamericana, Apartado 21827, Caracas 1020A, Venezuela

Received 12 March 2014; Accepted 11 July 2014; Published 24 July 2014

Academic Editor: George Perry

Copyright © 2014 Ninomar Mundaray Fernández and Mercedes Fernández-Mestre. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. PAHO-Pan American Health Organization, http://www1.paho.org/english/AD/DPC/CD/dch-poster.htm.
  2. S. M. H. Sadrzadeh and J. Bozorgmehr, “Haptoglobin phenotypes in health and disorders,” The American Journal of Clinical Pathology, vol. 121, supplement 1, pp. S97–S104, 2004. View at Google Scholar · View at Scopus
  3. J. Javid, “Human haptoglobins.,” Current Topics in Hematology, vol. 1, pp. 151–192, 1978. View at Google Scholar · View at Scopus
  4. M. R. Langlois and J. R. Delanghe, “Biological and clinical significance of haptoglobin polymorphism in humans,” Clinical Chemistry, vol. 42, no. 10, pp. 1589–1600, 1996. View at Google Scholar · View at Scopus
  5. P. M. Guéye, N. Glasser, G. Férard, and J. Lessinger, “Influence of human haptoglobin polymorphism on oxidative stress induced by free hemoglobin on red blood cells,” Clinical Chemistry and Laboratory Medicine, vol. 44, no. 5, pp. 542–547, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Asleh, S. Marsh, M. Shilkrut et al., “Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease,” Circulation Research, vol. 92, no. 11, pp. 1193–1200, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Guetta, M. Strauss, N. S. Levy, L. Fahoum, and A. P. Levy, “Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin,” Atherosclerosis, vol. 191, no. 1, pp. 48–53, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. D. R. Calderoni, S. Andrade, and H. Z. Grotto, “Haptoglobin phenotype appears to affect the pathogenesis of American trypanosomiasis,” Annals of Tropical Medicine and Parasitology, vol. 100, no. 3, pp. 213–221, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. S. E. D. C. Jorge, C. F. Abreu, M. E. Guariento, and M. D. F. Sonati, “Haptoglobin genotypes in Chagas' disease,” Clinical Biochemistry, vol. 43, no. 3, pp. 314–316, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Acquatella, F. Catalioti, J. R. Gomez-Mancebo, V. Davalos, and L. Villalobos, “Long-term control of Chagas disease in Venezuela: effects on serologic findings, electrocardiographic abnormalities, and clinical outcome,” Circulation, vol. 76, no. 3, pp. 556–562, 1987. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Bunce, “PCR-SSP typing in histocompatibility testing,” in Bidwell and Navarrette C, pp. 149–186, Imperial Collage Press, London, UK, 2000. View at Google Scholar
  12. W. Koch, W. Latz, M. Eichinger et al., “Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR,” Clinical Chemistry, vol. 48, no. 9, pp. 1377–1382, 2002. View at Google Scholar · View at Scopus
  13. B. Woolf, “On estimating the relation between blood group and disease,” Annals of Human Genetics, vol. 19, no. 4, pp. 251–253, 1955. View at Google Scholar
  14. I. K. Quaye, “Haptoglobin, inflammation and disease,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 102, no. 8, pp. 735–742, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. W. O. Dutra and K. J. Gollob, “Current concepts in immunoregulation and pathology of human Chagas disease,” Current Opinion in Infectious Diseases, vol. 21, no. 3, pp. 287–292, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. K. E. J. Tripodi, S. M. Menendez Bravo, and J. A. Cricco, “Role of heme and heme-proteins in trypanosomatid essential metabolic pathways,” Enzyme Research, vol. 2011, Article ID 873230, 12 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. V. G. Loo and R. G. Lalonde, “Role of iron in intracellular growth of Trypanosoma cruzi,” Infection and Immunity, vol. 45, no. 3, pp. 726–730, 1984. View at Google Scholar · View at Scopus
  18. M. Melamed-Frank, O. Lache, B. I. Enav et al., “Structure-function analysis of the antioxidant properties of haptoglobin,” Blood, vol. 98, no. 13, pp. 3693–3698, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. H. van Vlierberghe, M. Langlois, and J. Delanghe, “Haptoglobin polymorphisms and iron homeostasis in health and in disease,” Clinica Chimica Acta, vol. 345, no. 1-2, pp. 35–42, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Gupta, J.-J. Wen, and N. J. Garg, “Oxidative stress in chagas disease,” Interdisciplinary Perspectives on Infectious Diseases, vol. 2009, Article ID 190354, 8 pages, 2009. View at Publisher · View at Google Scholar